Sabkomelin

Sabkomelin
(IUPAC) ime
	(3R)-N-metoksihinuklidin-3-karboksimidoil cijanid hidrohlorid
Klinički podaci
Identifikatori
CAS broj	159912-58-0
ATC kod	nije dodeljen
PubChem	9577995
ChemSpider	7852359
UNII	P8P92V596C
ChEMBL	CHEMBL134641
Hemijski podaci
Formula	C10H15N3O
Mol. masa	193,12 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C10H15N3O/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13/h8-9H,2-5,7H2,1H3/b12-10+ ; Key: IQWCBYSUUOFOMF-ZRDIBKRKSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije odobren

Sabkomelin (Memrik, SB-202,026) je selektivni parcijalni agonist M₁ receptora. On je bio u razvoju za lečenje Alchajmerove bolesti.^[5] Sabkomelin je dospeo do faze III kliničkih ispitivanja, ali su dalja ispitivanja prekinuta zbog loših rezultata.

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Loudon JM, Bromidge SM, Brown F, et al. (December 1997). „SB 202026: a novel muscarinic partial agonist with functional selectivity for M1 receptors”. The Journal of Pharmacology and Experimental Therapeutics 283 (3): 1059–68. PMID 9399977.

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