SKF-38393 je sintetičko jedinjenje iz benzazepinske hemijske klase koje deluje kao selektivni parcijalni agonist D1/D5 receptora.[5] On ima stimulansno i anoreksičko dejstvo.[6][7]
SKF-38393
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| (IUPAC) ime
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| 1-fenil-2,3,4,5-tetrahidro-1H-3-benzazepin-7,8-diol
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| Klinički podaci
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| Identifikatori
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| CAS broj
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67287-49-4
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| ATC kod
|
nije dodeljen
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| PubChem[1][2]
|
1242
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| ChemSpider[3]
|
1205
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| ChEMBL[4]
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CHEMBL24077  Y
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| Hemijski podaci
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| Formula
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C16H17NO2
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| Mol. masa
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255,31 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2 Y
Key: JUDKOGFHZYMDMF-UHFFFAOYSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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|
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Dubois A, Savasta M, Curet O, Scatton B (September 1986). „Autoradiographic distribution of the D1 agonist [3HSKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors”]. Neuroscience 19 (1): 125–37. DOI:10.1016/0306-4522(86)90010-2. PMID 2946980.
- ↑ Trampus M, Ferri N, Adami M, Ongini E (April 1993). „The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat”. European Journal of Pharmacology 235 (1): 83–7. DOI:10.1016/0014-2999(93)90823-Z. PMID 8100197.
- ↑ Cooper SJ, Francis J, Rusk IN (1990). „The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour”. Psychopharmacology 100 (2): 182–7. DOI:10.1007/BF02244403. PMID 1968277.
