S1PR3

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Sfingozin-1-fosfatni receptor 3 je ljudski gen koji kodira G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin 1-fosfat (S1P). stoga je ovaj receptor takođe poznat kao S1P₃.

Sfingozin-1-fosfatni receptor 3
Identifikatori
Simboli	S1PR3; EDG-3; EDG3; LPB3; S1P3
Vanjski ID	OMIM: 601965 MGI: 1339365 HomoloGene: 3829 IUPHAR: S1P3
Ontologija gena Molekularna funkcija • aktivnost G-protein spregnutog receptora • aktivnost faktora guanil-nukleotidne razmene • vezivanje masne kiseline Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • metabolički proces energetske rezerve • signalni put G-protein spregnutog receptora • pozitivna regulacija kalcijumskog jonskog transporta u citozol
Ortolozi
Vrsta	Čovek	Miš
Entrez	n/a	13610
Ensembl	ENSG00000213694	ENSMUSG00000067586
UniProt	Q99500	Q9Z0U9
RefSeq (mRNA)	NM_005226.3	NM_010101.4
RefSeq (protein)	NP_005217.2	NP_034231.1
Lokacija (UCSC)	Chr 9: 91.61 - 91.62 Mb	Chr 13: 51.5 - 51.52 Mb
PubMed pretraga	n/a	[1]

Funkcija

Ovaj protein je član EDG familije receptora. On doprinosi regulaciji angiogeneze i funkcija vaskularnih endotelnih ćelija.

Literatura

• Hla T, Lee MJ, Ancellin N, et al. (2000). „Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.”. Ann. N. Y. Acad. Sci. 905: 16–24. DOI:10.1111/j.1749-6632.2000.tb06534.x. PMID 10818438. 
• Spiegel S (2000). „Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.”. Ann. N. Y. Acad. Sci. 905: 54–60. DOI:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441. 
• Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). „Phospholipid growth factors and corneal wound healing.”. Ann. N. Y. Acad. Sci. 905: 142–58. DOI:10.1111/j.1749-6632.2000.tb06546.x. PMID 10818450. 
• Takuwa Y (2002). „[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]”. Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. PMID 11915348. 
• Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, et al. (1996). „A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.”. Mol. Pharmacol. 49 (6): 956–61. PMID 8649355. 
• Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). „Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.”. Biochem. Biophys. Res. Commun. 227 (2): 608–14. DOI:10.1006/bbrc.1996.1553. PMID 8878560. 
• An S, Bleu T, Huang W, et al. (1998). „Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.”. FEBS Lett. 417 (3): 279–82. DOI:10.1016/S0014-5793(97)01301-X. PMID 9409733. 
• Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). „Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.”. J. Biol. Chem. 274 (8): 4626–32. DOI:10.1074/jbc.274.8.4626. PMID 9988698. 
• Zhang Q, Peyruchaud O, French KJ, et al. (1999). „Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway.”. Blood 93 (9): 2984–90. PMID 10216094. 
• Ancellin N, Hla T (1999). „Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.”. J. Biol. Chem. 274 (27): 18997–9002. DOI:10.1074/jbc.274.27.18997. PMID 10383399. 
• Windh RT, Lee MJ, Hla T, et al. (1999). „Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.”. J. Biol. Chem. 274 (39): 27351–8. DOI:10.1074/jbc.274.39.27351. PMID 10488065. 
• Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). „Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.”. Cancer Res. 59 (20): 5370–5. PMID 10537322. 
• Lee MJ, Thangada S, Claffey KP, et al. (1999). „Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.”. Cell 99 (3): 301–12. DOI:10.1016/S0092-8674(00)81661-X. PMID 10555146. 
• An S, Zheng Y, Bleu T (2000). „Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.”. J. Biol. Chem. 275 (1): 288–96. DOI:10.1074/jbc.275.1.288. PMID 10617617. 
• Orlati S, Porcelli AM, Hrelia S, et al. (2000). „Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor.”. Arch. Biochem. Biophys. 375 (1): 69–77. DOI:10.1006/abbi.1999.1589. PMID 10683250. 
• Lee H, Goetzl EJ, An S (2000). „Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing.”. Am. J. Physiol., Cell Physiol. 278 (3): C612–8. PMID 10712250. 
• Kimura T, Watanabe T, Sato K, et al. (2000). „Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.”. Biochem. J. 348 Pt 1: 71–6. DOI:10.1042/0264-6021:3480071. PMID 10794715. 

Vidi još

• Lizofosfolipidni receptor

Spoljašnje veze

• „Lysophospholipid Receptors: S₁P₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
• MeSH Lysophospholipid+receptors