Riboza 5-fosfat

Riboza 5-fosfat
	(2,3,4-Trihidroksi-5-okso-pentoksi)fosfonska kiselina
Identifikacija
CAS registarski broj	3615-55-2
PubChem	230
MeSH	ribose-5-phosphate
Jmol-3D slike	Slika 1
SMILES
	C(C(C(C(C=O)O)O)O)OP(=O)(O)O
Svojstva
Molekulska formula	C5H11O8P
Molarna masa	230.110
	; ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Riboza 5-fosfat je proizvod i intermedijar pentozno fosfatnog puta^[5]^[6]. Zadnji stupanj oksidativnih reakcija pentozno fosfatnog puta je proizvodnja ribuloza 5-fosfata. U zavisnosti od stanja tela, ribuloza 5-fosfat može podleći revizibilnoj izomerizaciji u riboza 5-fosfat ^[7]^[8]. Ribuloza 5-fosfat može alternativno podleći seriji izomerizacija kao i transaldolacija i transketolacija koje rezultuju u produkciji drugih pentozo fosfata, kao i fruktoza 6-fosfata i gliceraldehid-3-fosfata (koji su intermedijari u glikolizi)^[9].

Enzim riboza-fosfat difosfokinaza^[10] pretvara riboza 5-fosfat u fosforibozil pirofosfat.

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Lide David R., ur. (2006). CRC Handbook of Chemistry and Physics (87th izd.). Boca Raton, FL: CRC Press. 0-8493-0487-3.
↑ Susan Budavari, ur. (2001). The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (13th izd.). Merck Publishing. ISBN 0-911910-13-1.
↑ „Pentose phosphate pathway (hexose monophosphate shunt)”. Arhivirano iz originala na datum 2010-03-01. Pristupljeno 2014-04-11.
↑ Wamelink MM, Struys EA, Jakobs C (2008). „The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review”. J Inherit Metab Dis 31: 703-17. PMID 18987987.
↑ Zhang, R; Andersson, CE; Savchenko, A; Skarina, T; Evdokimova, E; Beasley, S; Arrowsmith, CH; Edwards, AM i dr.. (2003). „Structure of Escherichia coli Ribose-5-Phosphate IsomeraseA Ubiquitous Enzyme of the Pentose Phosphate Pathway and the Calvin Cycle”. Structure 11 (1): 31. DOI:10.1016/S0969-2126(02)00933-4. PMC 2792023. PMID 12517338.
↑ Jung, Ch; Hartman, Fc; Lu, Ty; Larimer, Fw (Jan 2000). „D-ribose-5-phosphate isomerase from spinach: heterologous overexpression, purification, characterization, and site-directed mutagenesis of the recombinant enzyme”. Archives of biochemistry and biophysics 373 (2): 409–17. DOI:10.1006/abbi.1999.1554. ISSN 0003-9861. PMID 10620366.
↑ Horecker B. L., Smyrniotis P. Z., Seegmiller J. E. (1951). „The enzymatic conversion of 6-phosphogluconate to ribulose-5-phosphate and ribose-5-phosphate”. J. Biol. Chem. 193 (1): 383-96. PMID 14907726.
↑ Diethmar S (2007). Handbook of Enzymes (2 izd.). Springer. str. 1-22. DOI:10.1007/978-3-540-71526-9_1. ISBN 978-3-540-71525-2. ^{[mrtav link]}

Literatura uredi

Diethmar S (2007). Handbook of Enzymes (2 izd.). Springer. str. 1-22. DOI:10.1007/978-3-540-71526-9_1. ISBN 978-3-540-71525-2. ^{[mrtav link]}

Spoljašnje veze uredi

Portal Hemija

Pentozno fosfatni put Arhivirano 2010-04-30 na Wayback Machine-u
PubChem

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[CRC-3] Lide David R., ur. (2006). CRC Handbook of Chemistry and Physics (87th izd.). Boca Raton, FL: CRC Press. 0-8493-0487-3.

[Merck13th-4] Susan Budavari, ur. (2001). The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (13th izd.). Merck Publishing. ISBN 0-911910-13-1.

[Pentose_phosphate_pathway-5] „Pentose phosphate pathway (hexose monophosphate shunt)”. Arhivirano iz originala na datum 2010-03-01. Pristupljeno 2014-04-11.

[Wamelink-6] Wamelink MM, Struys EA, Jakobs C (2008). „The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review”. J Inherit Metab Dis 31: 703-17. PMID 18987987.

[7] Zhang, R; Andersson, CE; Savchenko, A; Skarina, T; Evdokimova, E; Beasley, S; Arrowsmith, CH; Edwards, AM i dr.. (2003). „Structure of Escherichia coli Ribose-5-Phosphate IsomeraseA Ubiquitous Enzyme of the Pentose Phosphate Pathway and the Calvin Cycle”. Structure 11 (1): 31. DOI:10.1016/S0969-2126(02)00933-4. PMC 2792023. PMID 12517338.

[Jung-8] Jung, Ch; Hartman, Fc; Lu, Ty; Larimer, Fw (Jan 2000). „D-ribose-5-phosphate isomerase from spinach: heterologous overexpression, purification, characterization, and site-directed mutagenesis of the recombinant enzyme”. Archives of biochemistry and biophysics 373 (2): 409–17. DOI:10.1006/abbi.1999.1554. ISSN 0003-9861. PMID 10620366.

[9] Horecker B. L., Smyrniotis P. Z., Seegmiller J. E. (1951). „The enzymatic conversion of 6-phosphogluconate to ribulose-5-phosphate and ribose-5-phosphate”. J. Biol. Chem. 193 (1): 383-96. PMID 14907726.

[Ribose-phosphate_diphosphokinase-10] Diethmar S (2007). Handbook of Enzymes (2 izd.). Springer. str. 1-22. DOI:10.1007/978-3-540-71526-9_1. ISBN 978-3-540-71525-2. ^{[mrtav link]}

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