RAIG (Retinoinskom kiselinom inducibilni orfan G protein spregnuti receptori) su grupa od četiri blisko srodna G protein spregnuta receptora čije izražavanje je indukovano retinoinskom kiselinom.[1][2][3][4]
Funkcija ovih proteina nije određena. Pretpostavlja se da oni mogu da pruže mehanizam kojim retinoinska kiselina može da utiče na G proteinsku signalnu kaskadu. Osim toga, RAIG receptori formiraju interakcije sa članovima klase uvojitih G protein spregnutih receptora i potencijalno aktiviraju Wnt signalni put.[5]
- ↑ Cheng Y, Lotan R (1998). „Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor”. J. Biol. Chem. 273 (52): 35008–15. DOI:10.1074/jbc.273.52.35008. PMID 9857033.
- ↑ Bräuner-Osborne H, Krogsgaard-Larsen P (2000). „Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain”. Genomics 65 (2): 121–8. DOI:10.1006/geno.2000.6164. PMID 10783259.
- ↑ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). „Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)”. Genomics 67 (1): 8–18. DOI:10.1006/geno.2000.6226. PMID 10945465.
- ↑ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). „Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D”. Biochim. Biophys. Acta 1518 (3): 237–48. PMID 11311935.
- ↑ Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). „Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling”. Biochem. Biophys. Res. Commun. 358 (4): 968–75. DOI:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.
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