Receptor slobodnih masnih kiselina 1

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Receptor slobodnih masnih kiselina 1 (FFA1) je G protein spregnuti receptor kodiran ljudskim genom FFAR1. On je u znatnoj meri izražen u ćelijama pankreasa, a u manjoj meri u materici i mozgu.

Receptor slobodnih masnih kiselina 1
Identifikatori
Simboli	FFAR1; FFA1R; GPCR40; GPR40
Vanjski ID	OMIM: 603820 MGI: 2684079 HomoloGene: 3876 IUPHAR: FFA1 GeneCards: FFAR1 Gene
Ontologija gena Molekularna funkcija • aktivnost G-protein spregnutog receptora • aktivnost faktora guanil-nukleotidne razmene • vezivanje masne kiseline Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • metabolički proces energetske rezerve • signalni put G-protein spregnutog receptora • pozitivna regulacija kalcijumskog jonskog transporta u citozol
Ortolozi
Vrsta	Čovek	Miš
Entrez	2864	233081
Ensembl	ENSG00000126266	ENSMUSG00000044453
UniProt	O14842	Q76JU9
RefSeq (mRNA)	NM_005303.2	NM_194057.2
RefSeq (protein)	NP_005294.1	NP_918946.2
Lokacija (UCSC)	Chr 19: 35.84 - 35.84 Mb	Chr 7: 31.65 - 31.65 Mb
PubMed pretraga	[1]	[2]

Literatura

• Brown AJ, Jupe S, Briscoe CP (2005). „A family of fatty acid binding receptors.”. DNA Cell Biol. 24 (1): 54–61. DOI:10.1089/dna.2005.24.54. PMID 15684720. 
• Sawzdargo M, George SR, Nguyen T, et al. (1997). „A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.”. Biochem. Biophys. Res. Commun. 239 (2): 543–7. DOI:10.1006/bbrc.1997.7513. PMID 9344866. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Briscoe CP, Tadayyon M, Andrews JL, et al. (2003). „The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.”. J. Biol. Chem. 278 (13): 11303–11. DOI:10.1074/jbc.M211495200. PMID 12496284. 
• Kotarsky K, Nilsson NE, Flodgren E, et al. (2003). „A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.”. Biochem. Biophys. Res. Commun. 301 (2): 406–10. DOI:10.1016/S0006-291X(02)03064-4. PMID 12565875. 
• Itoh Y, Kawamata Y, Harada M, et al. (2003). „Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.”. Nature 422 (6928): 173–6. DOI:10.1038/nature01478. PMID 12629551. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Hardy S, St-Onge GG, Joly E, et al. (2005). „Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40.”. J. Biol. Chem. 280 (14): 13285–91. DOI:10.1074/jbc.M410922200. PMID 15695516. 
• Ogawa T, Hirose H, Miyashita K, et al. (2005). „GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men.”. Metab. Clin. Exp. 54 (3): 296–9. DOI:10.1016/j.metabol.2004.09.008. PMID 15736105. 
• Tomita T, Masuzaki H, Noguchi M, et al. (2006). „GPR40 gene expression in human pancreas and insulinoma.”. Biochem. Biophys. Res. Commun. 338 (4): 1788–90. DOI:10.1016/j.bbrc.2005.10.161. PMID 16289108. 
• Tomita T, Masuzaki H, Iwakura H, et al. (2006). „Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.”. Diabetologia 49 (5): 962–8. DOI:10.1007/s00125-006-0193-8. PMID 16525841. 
• Stoddart LA, Brown AJ, Milligan G (2007). „Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist.”. Mol. Pharmacol. 71 (4): 994–1005. DOI:10.1124/mol.106.031534. PMID 17200419. 
• Bartoov-Shifman R, Ridner G, Bahar K, et al. (2007). „Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells.”. J. Biol. Chem. 282 (32): 23561–71. DOI:10.1074/jbc.M702115200. PMID 17525159. 
• Sum CS, Tikhonova IG, Neumann S, et al. (2007). „Identification of residues important for agonist recognition and activation in GPR40.”. J. Biol. Chem. 282 (40): 29248–55. DOI:10.1074/jbc.M705077200. PMID 17699519. 

Vidi još

• Receptor slobodnih masnih kiselina

Spoljašnje veze

• „Free Fatty Acid Receptors: FFA1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-04.