RXFP1

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RXFP1, relaksinu/insulinu-slična familija, peptidni receptor 1, je humani G-protein spregnuti receptor.

Relaksinu/insulinu-slična familija, peptidni receptor 1
PDB rendering based on 2jm4.
Dostupne strukture
2jm4
Identifikatori
Simboli	RXFP1; LGR7; LGR7.1; LGR7.10; LGR7.2; MGC138347; MGC142177
Vanjski ID	OMIM: 606654 MGI: 2682211 HomoloGene: 11007 IUPHAR: RXFP1 GeneCards: RXFP1 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • proteinsko vezivanje • hormonsko vezivanje Celularna komponenta • integralno sa ćelijskom membranom • membrana Biološki proces • prenos signala • signalni put G-protein spregnutog receptora • organizacija ekstracelularnog matriksa i biogeneza • razvoj mlečnih žlezda
Ortolozi
Vrsta	Čovek	Miš
Entrez	59350	381489
Ensembl	ENSG00000171509	ENSMUSG00000034009
UniProt	Q9HBX9	n/a
RefSeq (mRNA)	NM_021634	NM_212452
RefSeq (protein)	NP_067647	NP_997617
Lokacija (UCSC)	Chr 4: 159.66 - 159.79 Mb	Chr 3: 79.73 - 79.82 Mb
PubMed pretraga	[1]	[2]

Vidi još

• Relaksinski receptor

Literatura

• Bathgate RA, Ivell R, Sanborn BM, et al. (2005). „Receptors for relaxin family peptides.”. Ann. N. Y. Acad. Sci. 1041: 61–76. DOI:10.1196/annals.1282.010. PMID 15956688. 
• Bathgate RA, Ivell R, Sanborn BM, et al. (2006). „International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.”. Pharmacol. Rev. 58 (1): 7–31. DOI:10.1124/pr.58.1.9. PMID 16507880. 
• Hsu SY, Kudo M, Chen T, et al. (2001). „The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7.”. Mol. Endocrinol. 14 (8): 1257–71. DOI:10.1210/me.14.8.1257. PMID 10935549. 
• Bartsch O, Bartlick B, Ivell R (2001). „Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity.”. Mol. Hum. Reprod. 7 (9): 799–809. DOI:10.1093/molehr/7.9.799. PMID 11517286. 
• Hsu SY, Nakabayashi K, Nishi S, et al. (2002). „Activation of orphan receptors by the hormone relaxin.”. Science 295 (5555): 671–4. DOI:10.1126/science.1065654. PMID 11809971. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Sudo S, Kumagai J, Nishi S, et al. (2003). „H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2.”. J. Biol. Chem. 278 (10): 7855–62. DOI:10.1074/jbc.M212457200. PMID 12506116. 
• Ivell R, Balvers M, Pohnke Y, et al. (2004). „Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates.”. Reprod. Biol. Endocrinol. 1: 114. DOI:10.1186/1477-7827-1-114. PMC 293425. PMID 14633277. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Luna JJ, Riesewijk A, Horcajadas JA, et al. (2004). „Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle.”. Mol. Hum. Reprod. 10 (2): 85–90. DOI:10.1093/molehr/gah019. PMID 14742692. 
• Bond CP, Parry LJ, Samuel CS, et al. (2004). „Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle.”. J. Clin. Endocrinol. Metab. 89 (7): 3477–85. DOI:10.1210/jc.2003-030798. PMID 15240635. 
• Liu C, Chen J, Kuei C, et al. (2005). „Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.”. Mol. Pharmacol. 67 (1): 231–40. DOI:10.1124/mol.104.006700. PMID 15465925. 
• Scott DJ, Layfield S, Riesewijk A, et al. (2005). „Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7.”. Clin. Exp. Pharmacol. Physiol. 31 (11): 828–32. DOI:10.1111/j.1440-1681.2004.04075.x. PMID 15566402. 
• Büllesbach EE, Schwabe C (2005). „The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7.”. J. Biol. Chem. 280 (14): 14051–6. DOI:10.1074/jbc.M500030200. PMID 15695505. 
• Tang M, Mazella J, Zhu HH, Tseng L (2005). „Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells.”. Mol. Hum. Reprod. 11 (4): 237–43. DOI:10.1093/molehr/gah149. PMID 15722441. 
• Hopkins EJ, Bathgate RA, Gooley PR (2005). „The human LGR7 low-density lipoprotein class A module requires calcium for structure.”. Ann. N. Y. Acad. Sci. 1041: 27–34. DOI:10.1196/annals.1282.006. PMID 15956684. 
• Bond CP, Parry LJ, Samuel CS, et al. (2005). „Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle.”. Ann. N. Y. Acad. Sci. 1041: 136–43. DOI:10.1196/annals.1282.020. PMID 15956698. 
• Halls ML, Bathgate RA, Summers RJ (2005). „Signal switching after stimulation of LGR7 receptors by human relaxin 2.”. Ann. N. Y. Acad. Sci. 1041: 288–91. DOI:10.1196/annals.1282.042. PMID 15956719. 
• Muda M, He C, Martini PG, et al. (2005). „Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.”. Mol. Hum. Reprod. 11 (8): 591–600. DOI:10.1093/molehr/gah205. PMID 16051677. 

Spoljašnje veze

• „Relaxin Family Peptide Receptors: RXFP1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.