Pseudouridin

Pseudouridin
	5-[(2S,3R,4S,5R)-3,4-Dihidroksi-5-(hidroksimetil)-oksolan-2-il]-1H-pirimidin-2,4-dion
	Preferentno IUPAC ime 5-(β-D-ribofuranozil)pirimidin-2,4(1H,3H)-dion
Drugi nazivi	psi-uridin, 5-Riboziluracil, beta-D-pseudouridin, 5-(beta-D-ribofuranozil)uracil
Identifikacija
CAS registarski broj	1445-07-4
PubChem	15047
ChemSpider	14319
ChEBI	17802
Jmol-3D slike	Slika 1
SMILES
	O=C1N\C=C(/C(=O)N1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
InChI
	InChI=1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1 ; Kod: PTJWIQPHWPFNBW-GBNDHIKLSA-N InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1; Kod: PTJWIQPHWPFNBW-GBNDHIKLBY InChI=1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1; Kod: PTJWIQPHWPFNBW-GBNDHIKLSA-N
Svojstva
Molekulska formula	C9H12N2O6
Molarna masa	244,20 g/mol
Agregatno stanje	Beli granularni prah
Rastvorljivost u vodi	Visoko rastvoran u vodi
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Pseudouridin (Ψ) je C-glikozidni izomer nukleozida uridina. On je najprevalentniji iz grupe od preko sto različitih nukleozida nađenih u RNK.^[4] Ψ je prisutan kod svih vrsta i u mnogim klasama RNK izuzev iRNK.^[5]^[6] Ψ formiraju enzimi Ψ sintaze, koji posttranskripciono izomerizuju specifične uridinske ostatke u RNK u procesu pseudouridilacije.^[7]

Nedavna istraživanja sugeriraju da on možda daje izvesnu zaštitu od radijacije.^[8]

On se često javlja u tRNK, u asocijaciji sa timidinom i citozinom u TΨC ruci i jedan je od nepromenljivih regiona tRNK. Njegova funkcija nije potpuno razjašnjena. Smatra se da učestvuje u asocijaciji sa aminoacil transferazom tokom interakcije sa tRNK, i otuda u inicijaciji translacije.

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Hamma T, Ferré-D'Amaré AR (2006). „Pseudouridine synthases”. Chem. Biol. 13 (11): 1125–1135. DOI:10.1016/j.chembiol.2006.09.009. PMID 17113994.
↑ Charette M, Gray MW (2000). „Pseudouridine in RNA: what, where, how, and why”. IUBMB Life 49 (5): 341–351. DOI:10.1080/152165400410182. PMID 10902565.
↑ Liang XH, Xu YX, MIchaeli S (2002). „The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA”. RNA 8 (2): 237–246. DOI:10.1017/S1355838202018290. PMC 1370245. PMID 11911368.
↑ Ferré-D'Amaré AR (2003). „RNA-modifying enzymes”. Curr. Opin. Struct. Biol. 13 (1): 49–55. DOI:10.1016/S0959-440X(02)00002-7. PMID 12581659.
↑ Monobe, Manami; Arimoto-Kobayashi, Sakae; Ando, Koichi (2003). „β-Pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes”. Mutation research. Genetic toxicology and environmental mutagenesis 538 (1–2): 93–99. DOI:10.1016/S1383-5718(03)00094-9. PMID 12834758. Arhivirano iz originala na datum 2009-09-15. Pristupljeno 2014-04-11.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Hamma T, Ferré-D'Amaré AR (2006). „Pseudouridine synthases”. Chem. Biol. 13 (11): 1125–1135. DOI:10.1016/j.chembiol.2006.09.009. PMID 17113994.

[5] Charette M, Gray MW (2000). „Pseudouridine in RNA: what, where, how, and why”. IUBMB Life 49 (5): 341–351. DOI:10.1080/152165400410182. PMID 10902565.

[6] Liang XH, Xu YX, MIchaeli S (2002). „The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA”. RNA 8 (2): 237–246. DOI:10.1017/S1355838202018290. PMC 1370245. PMID 11911368.

[7] Ferré-D'Amaré AR (2003). „RNA-modifying enzymes”. Curr. Opin. Struct. Biol. 13 (1): 49–55. DOI:10.1016/S0959-440X(02)00002-7. PMID 12581659.

[8] Monobe, Manami; Arimoto-Kobayashi, Sakae; Ando, Koichi (2003). „β-Pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes”. Mutation research. Genetic toxicology and environmental mutagenesis 538 (1–2): 93–99. DOI:10.1016/S1383-5718(03)00094-9. PMID 12834758. Arhivirano iz originala na datum 2009-09-15. Pristupljeno 2014-04-11.

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