Protopin

Protopin
	7-Metil-6,8,9,16-tetrahidrobis[1,3]benzodioksolo[4,5-c:5',6'-g]azecin-15(7H)-on
Identifikacija
CAS registarski broj	130-86-9
PubChem	4970
ChEMBL	CHEMBL486179
Jmol-3D slike	Slika 1
SMILES
	c15cc3OCOc3cc5CCN(C)Cc2c(CC1=O)ccc4c2OCO4
Svojstva
Molekulska formula	C20H19NO5
Molarna masa	353,369 g/mol
Agregatno stanje	beli kristali
Gustina	1,399 g/cm3
Tačka topljenja	208 °C
Rastvorljivost u vodi	nerastvoran je
Rastvorljivost u hloroform	1:15
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Protopin je benzilizohinolinski alkaloid koji se javlja u maku^[5], Corydalis krtolama^[6] i drugim biljkama iz familije papaveraceae, kao i Fumaria officinalis.^[7] Utvrđeno je da inhibira histaminske H1 receptore i zgrušavanje krvi, i da deluje kao analgetik.^[8]

Reference uredi

↑ The Merck Index (9 izd.). New Jersey: Merck & Co. 1976. str. 1023.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ The Free Dictionary: Protopine
↑ Jiang, B; Cao, K; Wang, R (2004). „Inhibitory effect of protopine on K(ATP) channel subunits expressed in HEK-293 cells.”. European Journal of Pharmacology 506 (2): 93-100. DOI:10.1016/j.ejphar.2004.11.004. PMID 15588728.
↑ Vrba, J.; Vrublova, E.; Modriansky, M.; Ulrichova, J. (2011). „Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR”. Toxicology Letters 203 (2): 135-141. DOI:10.1016/j.toxlet.2011.03.015. PMID 21419197.
↑ Saeed, SA; Gilani, AH; Majoo, RU; Shah, BH (1997). „Anti-thrombotic and anti-inflammatory activities of protopine.”. Pharmacological research : the official journal of the Italian Pharmacological Society 36 (1): 1-7. DOI:10.1006/phrs.1997.0195. PMID 9368908.

Vidi još uredi

Protopin 6-monooksigenaza

Spoljašnje veze uredi

Portal Hemija

MeSH Protopine

[1] The Merck Index (9 izd.). New Jersey: Merck & Co. 1976. str. 1023.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] The Free Dictionary: Protopine

[6] Jiang, B; Cao, K; Wang, R (2004). „Inhibitory effect of protopine on K(ATP) channel subunits expressed in HEK-293 cells.”. European Journal of Pharmacology 506 (2): 93-100. DOI:10.1016/j.ejphar.2004.11.004. PMID 15588728.

[7] Vrba, J.; Vrublova, E.; Modriansky, M.; Ulrichova, J. (2011). „Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR”. Toxicology Letters 203 (2): 135-141. DOI:10.1016/j.toxlet.2011.03.015. PMID 21419197.

[8] Saeed, SA; Gilani, AH; Majoo, RU; Shah, BH (1997). „Anti-thrombotic and anti-inflammatory activities of protopine.”. Pharmacological research : the official journal of the Italian Pharmacological Society 36 (1): 1-7. DOI:10.1006/phrs.1997.0195. PMID 9368908.

[5]

[6]

[7]

[8]

[1]

[2]

[3]

[4]