Prostaglandinski F receptor
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Prostaglandinski F receptor (FP) je receptor za prostaglandin F2α. On je kodiran PTGFR genom.[1]
| Prostaglandinski F receptor (FP) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | PTGFR; FP | ||||||||||
| Vanjski ID | OMIM: 600563 MGI: 97796 HomoloGene: 741 IUPHAR: FP GeneCards: PTGFR Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5737 | 19220 | |||||||||
| Ensembl | ENSG00000122420 | ENSMUSG00000028036 | |||||||||
| UniProt | P43088 | P43117 | |||||||||
| RefSeq (mRNA) | NM_000959.3 | NM_008966.3 | |||||||||
| RefSeq (protein) | NP_000950.1 | NP_032992.1 | |||||||||
| Lokacija (UCSC) | Chr 1: 78.77 - 79.01 Mb | Chr 3: 151.46 - 151.5 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Ovaj protein je član familije G protein spregnutih receptora.
Dve transkriptne varijante koji kodiraju različite izoforme su nađene za ovaj gen.[1]
Funkcije uredi
Glavni efekti vezivanja prostaglandina za ovaj receptor su:
- kontrakcija materice
- bronhokonstrikcija[2]
Putem aktivacije ovog receptora, PGF2-alfa posreduje luteolizu[1], i može da učestvuje u modulaciji intraokularnog pritiska i kontrakcija glatkih mišića materice i sfinktera gastrointestinalnog trakta[3].
Ispitivanja na nokaut miševima sugeriraju da interakcije PGF2-alfa sa ovim receptorom u lutealnim ćelijama jajnika iniciraju luteolizu i tako indukuju porođaj.[4]
Reference uredi
- ↑ 1,0 1,1 1,2 „Entrez Gene: PTGFR prostaglandin F receptor (FP)”.
- ↑ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5:th ed., Churchill Livingstone 2003) Page 234
- ↑ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
- ↑ Sugimoto Y, Yamasaki A, Segi E i dr.. (1997). „Failure of parturition in mice lacking the prostaglandin F receptor”. Science 277 (5326): 681–3. DOI:10.1126/science.277.5326.681. PMID 9235889.
Literatura uredi
- Duncan AM, Anderson LL, Funk CD i dr.. (1995). „Chromosomal localization of the human prostanoid receptor gene family”. Genomics 25 (3): 740–2. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114.
- Lake S, Gullberg H, Wahlqvist J i dr.. (1995). „Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor”. FEBS Lett. 355 (3): 317–25. DOI:10.1016/0014-5793(94)01198-2. PMID 7988697.
- Bastien L, Sawyer N, Grygorczyk R i dr.. (1994). „Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype”. J. Biol. Chem. 269 (16): 11873–7. PMID 8163486.
- Funk CD, Furci L, FitzGerald GA i dr.. (1994). „Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype”. J. Biol. Chem. 268 (35): 26767–72. PMID 8253813.
- Abramovitz M, Boie Y, Nguyen T i dr.. (1994). „Cloning and expression of a cDNA for the human prostanoid FP receptor”. J. Biol. Chem. 269 (4): 2632–6. PMID 8300593.
- Sugimoto Y, Yamasaki A, Segi E i dr.. (1997). „Failure of parturition in mice lacking the prostaglandin F receptor”. Science 277 (5326): 681–3. DOI:10.1126/science.277.5326.681. PMID 9235889.
- Kunapuli P, Lawson JA, Rokach J, FitzGerald GA (1997). „Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha”. J. Biol. Chem. 272 (43): 27147–54. DOI:10.1074/jbc.272.43.27147. PMID 9341156.
- Betz R, Lagercrantz J, Kedra D i dr.. (1999). „Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene”. Biochem. Biophys. Res. Commun. 254 (2): 413–6. DOI:10.1006/bbrc.1998.9827. PMID 9918852.
- Kyveris A, Maruscak E, Senchyna M (2002). „Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR”. Mol. Vis. 8: 51–8. PMID 11951086.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Neuschäfer-Rube F, Engemaier E, Koch S i dr.. (2003). „Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor”. Biochem. J. 371 (Pt 2): 443–9. DOI:10.1042/BJ20021429. PMC 1223288. PMID 12519077.
- Zaragoza DB, Wilson R, Eyster K, Olson DM (2004). „Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene”. Biochim. Biophys. Acta 1676 (2): 193–202. DOI:10.1016/j.bbaexp.2003.11.004. PMID 14746914.
- Sales KJ, Milne SA, Williams AR i dr.. (2004). „Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways”. J. Clin. Endocrinol. Metab. 89 (2): 986–93. DOI:10.1210/jc.2003-031434. PMID 14764825.
- Vielhauer GA, Fujino H, Regan JW (2004). „Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor”. Arch. Biochem. Biophys. 421 (2): 175–85. DOI:10.1016/j.abb.2003.10.021. PMID 14984197.
- Jin P, Fu GK, Wilson AD i dr.. (2004). „PCR isolation and cloning of novel splice variant mRNAs from known drug target genes”. Genomics 83 (4): 566–71. DOI:10.1016/j.ygeno.2003.09.023. PMID 15028279.
- Sugino N, Karube-Harada A, Taketani T i dr.. (2004). „Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation”. J. Reprod. Dev. 50 (2): 215–25. DOI:10.1262/jrd.50.215. PMID 15118249.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Scott G, Jacobs S, Leopardi S i dr.. (2005). „Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation”. Exp. Cell Res. 304 (2): 407–16. DOI:10.1016/j.yexcr.2004.11.016. PMID 15748887.
- Mandal AK, Ray R, Zhang Z i dr.. (2005). „Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators”. J. Biol. Chem. 280 (38): 32897–904. DOI:10.1074/jbc.M502375200. PMID 16061484.
- Hébert RL, Carmosino M, Saito O, et al. (2005). „Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct.”. J. Biol. Chem. 280 (41): 35028–37. DOI:10.1074/jbc.M505852200. PMID 16096282.
Vidi još uredi
Spoljašnje veze uredi
- „Prostanoid Receptors: FP”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.