Prostaglandin F2alfa

Dinoprost trometamin
(IUPAC) ime
	(Z)-7-[(1R,2R,3R,5S)-3,5-dihidroksi-2-[(E,3S)- 3-hidroksiokt-1-enil]ciklopentil]hept-5-enoinska kiselina
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	551-11-1 38562-01-5
ATC kod	G02AD01
PubChem	5280363
DrugBank	DB01160
ChemSpider	4445570
KEGG	D01352
ChEMBL	CHEMBL815
Hemijski podaci
Formula	C20H34O5
Mol. masa	354,48 g/mol
InChI
	InChI=1S/C20H34O5.C4H11NO3/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25;5-4(1-6,2-7)3-8/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25);6-8H,1-3,5H2/b7-4-,13-12+;/t15-,16+,17+,18-,19+;/m0./s1 ; Key: IYGXEHDCSOYNKY-RZHHZEQLSA-N
Farmakokinetički podaci
Poluvreme eliminacije	3 do 6 sati amniotički fluid, manje od 1 minuta u krvnoj plazmi
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	Intravenozno (za indukovanje porođaja)

Prostaglandin F_2α (PGF_2α u prostanoidnoj nomenklaturi), farmaceutski naziv dinoprost (INN), prirodni prostaglandin koji se koristi u medicini za indukciju porođaja, i kao abortifacijent.

Kod domaćih životinja, on se proizvodi u materici nakon stimulacije oksitocinom, u slučaju da nije došlo do implantacije tokom folikularne faze. On deluje kao na corpus luteum da uzrokuje luteolizu, čime se formira corpus albicans i proizvodi progesteron. Dejstvo PGF_2α je zavisno od brojnih receptora na corpus luteum membrani.

PGF_2α izoforma 8-izo-PGF_2α je nađena u znatno povišenim količinama kod pacijenata sa endometriozom, tako da je potencijalno uzročni link sa stresom vezanim za endometriozu.^[6]

Mehanizam dejstva uredi

PGF_2α deluje putem vezivanja za prostaglandinski F receptor. On je komercijalno dostupan kao Latanoprost.

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Sharma, I.; Dhaliwal, L.; Saha, S.; Sangwan, S.; Dhawan, V. (2010). „Role of 8-iso-prostaglandin F2alpha and 25-hydroxycholesterol in the pathophysiology of endometriosis”. Fertility and Sterility 94 (1): 63–70. DOI:10.1016/j.fertnstert.2009.01.141. PMID 19324352.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Sharma, I.; Dhaliwal, L.; Saha, S.; Sangwan, S.; Dhawan, V. (2010). „Role of 8-iso-prostaglandin F2alpha and 25-hydroxycholesterol in the pathophysiology of endometriosis”. Fertility and Sterility 94 (1): 63–70. DOI:10.1016/j.fertnstert.2009.01.141. PMID 19324352.

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