Propentofilin

Propentofilin
(IUPAC) ime
	3-metil-1-(5-oksoheksil)-7-propil-3,7-dihidro-1H-purin-2,6-dion
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	55242-55-2
ATC kod	N06BC02 QC04AD90
PubChem	4938
UNII	5RTA398U4H
Hemijski podaci
Formula	C15H22N4O3
Mol. masa	306,360 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3 ; Key: RBQOQRRFDPXAGN-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Propentofilin (HWA 285) je ksantinski derivat sa mogućim neuroprotektivnim dejstvom.

Farmakologija uredi

On je inhibitor fosfodiesteraze.^[3] On takođe deluje kao inhibitor preuzimanja adenozina.^[4]^[5]^[6]

Upotreba uredi

On je izučavan za moguću primenu u tretiranju Alchajimerove bolesti i vaskularne demencije.^[7]^[8]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane Database Syst Rev (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440.
↑ Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane Database Syst Rev (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440.
↑ Salimi S, Fotouhi A, Ghoreishi A i dr.. (April 2008). „A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia”. Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (3): 726–732. DOI:10.1016/j.pnpbp.2007.11.021. PMID 18096287.
↑ Numagami Y, Marro PJ, Mishra OP, Delivoria-Papadopoulos M (June 1998). „Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet”. Neuroscience 84 (4): 1127–1133. DOI:10.1016/S0306-4522(97)00542-3. PMID 9578400.
↑ Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane database of systematic reviews (Online) (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440.
↑ Kittner B, Rössner M, Rother M (1997). „Clinical trials in dementia with propentofylline”. Ann. N. Y. Acad. Sci. 826: 307–316. DOI:10.1111/j.1749-6632.1997.tb48481.x. PMID 9329701.

Vidi još uredi

Pentoksifilin

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid12804440-3] Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane Database Syst Rev (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440.

[autogenerated1-4] Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane Database Syst Rev (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440.

[pmid18096287-5] Salimi S, Fotouhi A, Ghoreishi A i dr.. (April 2008). „A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia”. Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (3): 726–732. DOI:10.1016/j.pnpbp.2007.11.021. PMID 18096287.

[pmid9578400-6] Numagami Y, Marro PJ, Mishra OP, Delivoria-Papadopoulos M (June 1998). „Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet”. Neuroscience 84 (4): 1127–1133. DOI:10.1016/S0306-4522(97)00542-3. PMID 9578400.

[7] Frampton M, Harvey RJ, Kirchner V (2003). Frampton, Maria A. ur. „Propentofylline for dementia”. Cochrane database of systematic reviews (Online) (2): CD002853. DOI:10.1002/14651858.CD002853. PMID 12804440.

[8] Kittner B, Rössner M, Rother M (1997). „Clinical trials in dementia with propentofylline”. Ann. N. Y. Acad. Sci. 826: 307–316. DOI:10.1111/j.1749-6632.1997.tb48481.x. PMID 9329701.

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