Prolaktinski receptor
Prolaktinski receptor je kodiran genom na hromozomu 5p13-14. On je transmembranski receptor koji formira interakcije sa molekulom prolaktina.
| Prolaktinski receptor | |
|---|---|
| Identifikatori | |
| Simbol | PRLR |
| Entrez | 5618 |
| HUGO | 9446 |
| OMIM | 176761 |
| PDB | 1RW5 |
| RefSeq | NM_000949 |
| UniProt | P16471 |
| Drugi podaci | |
| Lokus | Hromozom 5 p13-p12 |
Ovaj receptor sadrži ekstracelularni region za koji se vezuje prolaktin, transmembranski region, i citoplasmatični region. Prolaktinski receptor je citokinski receptor.[1] On je deo kaskade sekundarnih glasnika koja obuhvata JAK-STAT put, JAK-RUSH put,[2][3] Ras-Raf-MAPK, i PI-3K.[4]
Postoje varijacije između prolaktinskih receptora izraženih u različitim tkivima.[5]
Reference uredi
- ↑ Prolactin: The multi-faceted potentiator of mammary growth and function. Trott JF, Schennink A, Petrie WK, Manjarin R, Vanklompenberg MK, Hovey RC. J Anim Sci. 2011 Dec 28.
- ↑ Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):143-9.
- ↑ Prolactin induces Jak2 phosphorylation of RUSHY195. Helmer RA, Dertien JS, Chilton BS. Mol Cell Endocrinol. 2011 May 16;338(1-2):79-83.
- ↑ The role of prolactin in mammary carcinoma. Clevenger CV, Furth PA, Hankinson SE, Schuler LA. Endocr Rev. 2003 Feb;24(1):1-27.
- ↑ Impact of prolactin receptor isoforms on reproduction. Binart N, Bachelot A, Bouilly J. Trends Endocrinol Metab. 2010 Jun;21(6):362-8.