Uracil/timin dehidrogenaza
Uracil/timin dehidrogenaza (EC 1.17.99.4, uracil oksidaza, uracil-timin oksidaza) je enzim sa sistematskim imenom uracil:akceptor oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Uracil/timin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.17.99.4 | ||||||||
| CAS broj | 9029-00-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) uracil + H2O + akceptor barbiturat + redukovani akceptor
- (2) timin + H2O + akceptor 5-metilbarbiturat + redukovani akceptor
Ovaj enzim formira deo oksidativnog puta degradacije pirimidina kod nekih mikroorganizama, zajedno sa EC 3.5.2.1 (barbiturazom) i EC 3.5.1.95 (N-malonilurejskom hidrolazom).
Reference uredi
- ↑ Hayaishi, O. and Kornberg, A. (1952). „Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes”. J. Biol. Chem. 197: 717-723. PMID 12981104.
- ↑ Wang, T.P. and Lampen, J.O. (1952). „Metabolism of pyrimidines by a soil bacterium”. J. Biol. Chem. 194: 775-783. PMID 14927671.
- ↑ Wang, T.P. and Lampen, J.O. (1952). „Uracil oxidase and the isolation of barbituric acid from uracil oxidation”. J. Biol. Chem. 194: 785-791. PMID 14927672.
- ↑ Lara, F.J.S. (1952). „On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations”. J. Bacteriol. 64: 279-285. PMID 14955523.
- ↑ Soong, C.L., Ogawa, J. and Shimizu, S. (2001). „Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase”. Biochem. Biophys. Res. Commun. 286: 222-226. PMID 11485332.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.