Rezistin

Rezistin
	; Kristalografska struktura heksamera mišjeg rezistina (N-terminus = plavo, C-terminus = crveno).
Dostupne strukture
	1rfx, 1rgx
Identifikatori
Simboli	RETN; ADSF; FIZZ3; MGC126603; MGC126609; RETN1; RSTN; XCP1
Vanjski ID	OMIM: 605565 MGI: 1888506 HomoloGene: 10703 GeneCards: RETN Gene
Ontologija gena
Molekularna funkcija	• hormonska aktivnost;
Celularna komponenta	• ekstracelularni region;
Biološki proces	• biološki proces;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Rezistin (sekretorni faktor specifičan za adipozno tkivo, ADSF, (engl. C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein), XCP1) je protein bogat cisteinom koji je kod ljudi kodiran RETN genom.^[2]

Kod primata, svinja, i pasa, rezistin izlučuju imune i epitelne ćelije, dok ga kod glodara izlučuje adipozno tkivo. Dužina rezistinskog prepeptida kod ljudi je 108 aminokiselina, a kod miševa i pacova 114 aminokiselina. Molekulska masa je ~12.5 kDa. Rezistin je citokin čija fiziološka uloga je bila kontroverzna u pogledu njegovog uticaja na gojaznost i tip II dijabetes melitus.^[3]

Otkriće uredi

Rezistin je otkrila grupa predvođena dr Mičelom Lazarom 2001 na Univerzitetu Pensilvanije u Školi za Medicinu.^[4] On je dobio ime „rezistin“ zato što je primećena insulinska rezistencija kod miševa nakon ubrizgavanja rezistina. Utvrđeno je da rezistin proizvodi i otpušta adipozno tkivo i da ima endokrine funkcije koje učestvuju u otpornosti na insulin. Ova ideja prvenstveno proizilazi iz sudija kojima je pokazano da se nivoi serumskog rezistina povećavaju sa gojaznošću u nekoliko model sistema (ljudi, pacovi, i miševi).^[4]^[5]^[6]^[7]^[8] U međuvremenu dalja istraživanja su povezala rezistin sa drugim fiziološkim sistemima kao što je inflamacija i energetska homeostaza.^[9]^[10]^[11]

Reference uredi

↑ PDB 1rfx; Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L (May 2004). „Disulfide-dependent multimeric assembly of resistin family hormones”. Science 304 (5674): 1154–8. DOI:10.1126/science.1093466. PMID 15155948.
↑ Wang H, Chu WS, Hemphill C, Elbein SC (June 2002). „Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians”. J. Clin. Endocrinol. Metab. 87 (6): 2520–4. DOI:10.1210/jc.87.6.2520. PMID 12050208.
↑ Lazar MA (October 2007). „Resistin- and Obesity-associated metabolic diseases”. Horm. Metab. Res. 39 (10): 710–6. DOI:10.1055/s-2007-985897. PMID 17952831.
↑ ^4,0 ^4,1 Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA (January 2001). „The hormone resistin links obesity to diabetes”. Nature 409 (6818): 307–12. DOI:10.1038/35053000. PMID 11201732.
↑ Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, Watson W, Kerr K, Jones R, Zhu Q, Considine RV (November 2003). „Serum resistin (FIZZ3) protein is increased in obese humans”. J. Clin. Endocrinol. Metab. 88 (11): 5452–5. DOI:10.1210/jc.2002-021808. PMID 14602788.
↑ Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N (October 2002). „Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?”. Diabetes 51 (10): 2951–8. DOI:10.2337/diabetes.51.10.2951. PMID 12351432.
↑ Levy JR, Davenport B, Clore JN, Stevens W (March 2002). „Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats”. Am. J. Physiol. Endocrinol. Metab. 282 (3): E626–33. DOI:10.1152/ajpendo.00346.2001. PMID 11832366.
↑ McTernan CL, McTernan PG, Harte AL, Levick PL, Barnett AH, Kumar S (January 2002). „Resistin, central obesity, and type 2 diabetes”. Lancet 359 (9300): 46–7. DOI:10.1016/S0140-6736(02)07281-1. PMID 11809189.
↑ Adeghate E (October 2004). „An update on the biology and physiology of resistin”. Cell. Mol. Life Sci. 61 (19–20): 2485–96. DOI:10.1007/s00018-004-4083-2. PMID 15526156.
↑ Stumvoll M, Häring H (November 2002). „Resistin and adiponectin--of mice and men”. Obes. Res. 10 (11): 1197–9. DOI:10.1038/oby.2002.162. PMID 12429885.
↑ Vendrell J, Broch M, Vilarrasa N, Molina A, Gómez JM, Gutiérrez C, Simón I, Soler J, Richart C (June 2004). „Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity”. Obes. Res. 12 (6): 962–71. DOI:10.1038/oby.2004.118. PMID 15229336.

Spoljašnje veze uredi

MeSH Resistin

[pmid15155948-1] PDB 1rfx; Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L (May 2004). „Disulfide-dependent multimeric assembly of resistin family hormones”. Science 304 (5674): 1154–8. DOI:10.1126/science.1093466. PMID 15155948.

[pmid12050208-2] Wang H, Chu WS, Hemphill C, Elbein SC (June 2002). „Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians”. J. Clin. Endocrinol. Metab. 87 (6): 2520–4. DOI:10.1210/jc.87.6.2520. PMID 12050208.

[pmid17952831-3] Lazar MA (October 2007). „Resistin- and Obesity-associated metabolic diseases”. Horm. Metab. Res. 39 (10): 710–6. DOI:10.1055/s-2007-985897. PMID 17952831.

[p30-4] 4,0 ^4,1 Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA (January 2001). „The hormone resistin links obesity to diabetes”. Nature 409 (6818): 307–12. DOI:10.1038/35053000. PMID 11201732.

[p4-5] Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, Watson W, Kerr K, Jones R, Zhu Q, Considine RV (November 2003). „Serum resistin (FIZZ3) protein is increased in obese humans”. J. Clin. Endocrinol. Metab. 88 (11): 5452–5. DOI:10.1210/jc.2002-021808. PMID 14602788.

[p8-6] Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N (October 2002). „Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?”. Diabetes 51 (10): 2951–8. DOI:10.2337/diabetes.51.10.2951. PMID 12351432.

[p16-7] Levy JR, Davenport B, Clore JN, Stevens W (March 2002). „Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats”. Am. J. Physiol. Endocrinol. Metab. 282 (3): E626–33. DOI:10.1152/ajpendo.00346.2001. PMID 11832366.

[p19-8] McTernan CL, McTernan PG, Harte AL, Levick PL, Barnett AH, Kumar S (January 2002). „Resistin, central obesity, and type 2 diabetes”. Lancet 359 (9300): 46–7. DOI:10.1016/S0140-6736(02)07281-1. PMID 11809189.

[p1-9] Adeghate E (October 2004). „An update on the biology and physiology of resistin”. Cell. Mol. Life Sci. 61 (19–20): 2485–96. DOI:10.1007/s00018-004-4083-2. PMID 15526156.

[p31-10] Stumvoll M, Häring H (November 2002). „Resistin and adiponectin--of mice and men”. Obes. Res. 10 (11): 1197–9. DOI:10.1038/oby.2002.162. PMID 12429885.

[p34-11] Vendrell J, Broch M, Vilarrasa N, Molina A, Gómez JM, Gutiérrez C, Simón I, Soler J, Richart C (June 2004). „Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity”. Obes. Res. 12 (6): 962–71. DOI:10.1038/oby.2004.118. PMID 15229336.

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