Protein-lizin 6-oksidaza
Protein-lizin 6-oksidaza (EC 1.4.3.13, lizil oksidaza) je enzim sa sistematskim imenom protein-L-lizin:kiseonik 6-oksidoreduktaza (deaminacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Protein-lizin 6-oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Protein-lizin 6-oksidaza homodimer, Komagataella pastoris | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.4.3.13 | ||||||||
| CAS broj | 99676-44-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- peptidil-L-lizil-peptid + O2 + H2O peptidil-alizil-peptid + NH3 +H2O2
On takođe deluje na protein 5-hidroksilizin. Ovaj enzim katalizuje final enzimski korak unakrsnog povezivanja kolagena i elastina u biosintezi normalnog odraslog ekstracelularnog matriksa.
Reference uredi
- ↑ Harris, E.D., Gonnerman, W.A., Savage, J.E. and O'Dell, B.L. (1974). „Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta”. Biochim. Biophys. Acta 341: 332-344. PMID 4838158.
- ↑ Rayton, J.K. and Harris, E.D. (1979). „Induction of lysyl oxidase with copper. Properties of an in vitro system”. J. Biol. Chem. 254: 621-626. PMID 33171.
- ↑ Stassen, F.L.H. (1976). „Properties of highly purified lysyl oxidase from embryonic chick cartilage”. Biochim. Biophys. Acta 438: 49-60. PMID 7318.
- ↑ Palamakumbura, A.H. and Trackman, P.C. (2002). „A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples”. Anal. Biochem. 300: 245-251. PMID 11779117.
- ↑ Kagan, H.M., Williams, M.A., Williamson, P.R. and Anderson, J.M. (1984). „Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates”. J. Biol. Chem. 259: 11203-11207. PMID 6147351.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.