Obestatin
Obestatin je putativni hormon koji se potencijalno proizvodi u ćelijama sluzokože želuca i tankih creva kod nekoliko sisara među kojima je čovek.[2] Obestatin je originalno bio identifikovan kao anoreksioni peptid, mada njegov uticaj na unos hrane ostaje kontroverzan.[3]
| Preprohormon grelin/obestatina | |
|---|---|
| |
| NMR structura obestatina u SDS / DPC micelnom rastvoru.[1] | |
| Identifikatori | |
| Simbol | GHRL |
| Entrez | 51738 |
| HUGO | 18129 |
| OMIM | 605353 |
| RefSeq | NM_016362 |
| UniProt | Q9UBU3 |
| Drugi podaci | |
| Lokus | Hromozom 3 p26-p25 |
Otkriće uredi
Istraživanja u Medicinskoj školi univerziteta u Stanfordu su identifikovala obestatin kao hormon 2005. godine. Do otkrića je došlo korišćenjem bioinformatičkog pristupa računarske pretrage sekvenciranih genoma nekoliko organizama.[4]
Vidi još uredi
Reference uredi
- ↑ PDB 2JSH; Scrima M, Campiglia P, Esposito C, Gomez-Monterrey I, Novellino E, D'Ursi AM (November 2007). „Obestatin conformational features: a strategy to unveil obestatin's biological role?”. Biochem. Biophys. Res. Commun. 363 (3): 500–5. DOI:10.1016/j.bbrc.2007.08.200. PMID 17904104.
- ↑ Gourcerol G, St-Pierre DH, Taché Y (June 2007). „Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?”. Regul. Pept. 141 (1-3): 1–7. DOI:10.1016/j.regpep.2006.12.023. PMID 17321609.
- ↑ Hassouna R, Zizzari P, Tolle V (July 2010). „The ghrelin/obestatin balance in the physiological and pathological control of growth hormone secretion, body composition and food intake”. J. Neuroendocrinol. 22 (7): 793–804. DOI:10.1111/j.1365-2826.2010.02019.x. PMID 20456603.
- ↑ Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ (November 2005). „Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake”. Science 310 (5750): 996–9. DOI:10.1126/science.1117255. PMID 16284174. Lay summary – New York Times.
Literatura uredi
- Holst B, Egerod KL, Schild E, et al. (2007). „GPR39 signaling is stimulated by zinc ions but not by obestatin”. Endocrinology 148 (1): 13–20. DOI:10.1210/en.2006-0933. PMID 16959833.
- Obestatin, novi fiziološki oponent grelina Arhivirano 2011-07-15 na Wayback Machine-u