Metil aminolevulinat

Metil aminolevulinat
(IUPAC) ime
	metil 5-amino-4-okso-pentanoat
Klinički podaci
AHFS/Drugs.com	Multum, informacije za potrošače
Identifikatori
CAS broj	33320-16-0
ATC kod	L01XD03
PubChem	16052023
DrugBank	DB00992
ChemSpider	13180320
ChEMBL	CHEMBL1096562
Hemijski podaci
Formula	C6H11NO3
Mol. masa	145,156 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C6H11NO3/c1-4(8)3-5(7)6(9)10-2/h5H,3,7H2,1-2H3 ; Key: FLQHIIVXMKXKFT-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Metil aminolevulinat (MAL, Metviks) je prolek koji se metaboliše do protoporfirina IX. On se koristi u fotodinamičkoj terapiji. Metviks krema se primenjuje topikalno.

Odobrenja i indikacije uredi

Metil aminolevulinat je odobren u mnogim zemljama za tretman nemelanomnog raka kože.^[5] Ovaj lek je odobren u Novom Zelandu za tretmant karcinoma bazalnih ćelija.^[6]

On ima izvesne prednosti u odnosu na Levulan.^[7]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ "New 5 Year Metvix-PDT Data Demonstrate Long-Term Efficacy & Reliability For NM Skin Cancer Treatment" 2006^{[mrtav link]}
↑ "Methyl aminolevulinate photodynamic therapy (MAL PDT)"
↑ Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009 by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

Šablon:Intracelularni hemoterapijski agensi

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] "New 5 Year Metvix-PDT Data Demonstrate Long-Term Efficacy & Reliability For NM Skin Cancer Treatment" 2006^{[mrtav link]}

[6] "Methyl aminolevulinate photodynamic therapy (MAL PDT)"

[7] Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009 by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T

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