Kalikrein plazme
Kalikrein plazme (EC 3.4.21.34, kininogenin, kalikrein I, kalikrein II, kininogenaza, kalikrein, kalikrein, glumorin, padreatin, padutin, kalidinogenaza, bradikininogenaza, pankeasni kalikrein, onokrein P, dilminal D, depot-Padutin, urokalikrein, urinarni kalikrein) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kalikrein plazme | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.34 | ||||||||
| CAS broj | 410538-33-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Selectivno razlaganje pojedinih tipova Arg- i Lys- veza, uključujući Lys-Arg - Arg-Ser i (ljudskom) kininogenu čime se oslobađa bradikinin
Ovaj enzim se formira iz prokalikreina iz plazme dejstvom faktora XIIa.
Reference uredi
- ↑ Heimark, R.L. and Davie, E.W. (1981). „Bovine and human plasma prekallikrein”. Methods Enzymol. 80: 157-172. PMID 6918767.
- ↑ McRae, B.J., Kurachi, K., Heimark, R.L., Fujikawa, K., Davie, E.W. and Powers, J.C. (1981). „Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates”. Biochemistry 20: 7196-7206. PMID 6976185.
- ↑ Silverberg, M. and Kaplan, A.P. (1988). „Prekallikrein”. Methods Enzymol. 163: 85-95. PMID 3237096.
- ↑ Seidah, N.G., Ladenheim, R., Mbikay, M., Hamelin, J., Lutfalla, G., Rougeon, F., Lazure, C. and Chrétien, M. (1989). „The cDNA structure of rat plasma kallikrein”. DNA 8: 563-574. PMID 2598771.
- ↑ Tsuda, Y., Teno, N., Okada, Y., Wanaka, K., Bohgaki, M., Hijikata-Okunomiya, A., Okamoto, U., Naito, T. and Okamoto, S. (1989). „Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein”. Chem. Pharm. Bull. 37: 3108-3111. PMID 2534361.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.