Glikogenin glukoziltransferaza
Glikogenin glukoziltransferaza (EC 2.4.1.186, glikogenin, prajmirajuća glukoziltransferaza, UDP-glukoza:glikogenin glukoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-glukoza:glikogenin alfa-D-glukoziltransferaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glikogenin glukoziltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.4.1.186 | ||||||||
| CAS broj | 117590-73-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- UDP-alfa-D-glukoza + glikogenin UDP + alfa-D-glukozilglikogenin
Ovaj enzim prvo katalizuje sopstvenu glukozilaciju, normalno na Tyr-194 proteina ako je grupa slobodna. On zatim vrši glukozilaciju glukozilnih grupa dok se formira molekul sa 5--13 ostataka. Dalje produžavanje glikogenskog lanca izvodi enzim EC 2.4.1.11, glikogen (skrob) sintaza.
Reference uredi
- ↑ Krisman, C.R. and Barengo, R. (1975). „A precursor of glycogen biosynthesis: α-1,4-glucan-protein”. Eur. J. Biochem. 52: 117-123. PMID 809265.
- ↑ Pitcher, J., Smythe, C., Campbell, D.G. and Cohen, P. (1987). „Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin”. Eur. J. Biochem. 169: 497-502. PMID 3121316.
- ↑ Pitcher, J., Smythe, C. and Cohen, P. (1988). „Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle”. Eur. J. Biochem. 176: 391-395. PMID 2970965.
- ↑ Kennedy, L.D., Kirkman, B.R., Lomako, J., Rodriguez, I.R. and Whelan, W.J. (1985). „The biogenesis of rabbit-muscle glycogen”. u: Berman, M.C. and Opie, L.A.. Membranes and Muscle. ICSU Press/IRL Press, Oxford. str. 65-84.
- ↑ Rodriguez, I.R. and Whelan, W.J. (1985). „A novel glycosyl-amino acid linkage: rabbit-muscle glycogen is covalently linked to a protein via tyrosine”. Biochem. Biophys. Res. Commun. 132: 829-836. PMID 4062948.
- ↑ Lomako, J., Lomako, W.M. and Whelan, W.J. (1988). „A self-glucosylating protein is the primer for rabbit muscle glycogen biosynthesis”. FASEB J. 2: 3097-3103. PMID 2973423.
- ↑ Alonso, M.D., Lomako, J., Lomako, W.M. and Whelan, W.J. (1995). „Catalytic activities of glycogenin additional to autocatalytic self-glucosylation”. J. Biol. Chem. 270: 15315-15319. PMID 7797519.
- ↑ Alonso, M.D., Lomako, J., Lomako, W.M. and Whelan, W.J. (1995). „A new look at the biogenesis of glycogen”. FASEB J. 9: 1126-1137. PMID 7672505.
- ↑ Mu, J. and Roach, P.J. (1998). „Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism”. J. Biol. Chem. 273: 34850-34856. PMID 9857012.
- ↑ Gibbons, B.J., Roach, P.J. and Hurley, T.D. (2002). „Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin”. J. Mol. Biol. 319: 463-177. PMID 12051921.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Kennedy, L.D., Kirkman, B.R., Lomako, J., Rodriguez, I.R. and Whelan, W.J. (1985). „The biogenesis of rabbit-muscle glycogen”. u: Berman, M.C. and Opie, L.A.. Membranes and Muscle. ICSU Press/IRL Press, Oxford. str. 65-84.