Gama-linolna kiselina

γ-Linolna kiselina
	sve-cis-6,9,12-oktadekatrienoinska kiselina
Drugi nazivi	Gama-linolna kiselina, gamolenska kiselina, GLA
Identifikacija
CAS registarski broj	506-26-3
PubChem	5280933
ChemSpider	4444436
UNII	78YC2MAX4O
ChEBI	28661
ChEMBL	CHEMBL464982
ATC code	D11AX02
Jmol-3D slike	Slika 1
SMILES
	O=C(O)CCCC\C=C/C\C=C/C\C=C/CCCCC
InChI
	InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12- ; Kod: VZCCETWTMQHEPK-QNEBEIHSSA-N InChI=1/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12-; Kod: VZCCETWTMQHEPK-QNEBEIHSBP
Svojstva
Molekulska formula	C18H30O2
Molarna masa	278.43 g mol−1
Agregatno stanje	Bezbojno ulje
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

γ-linolna kiselina (gama-linolna kiselina, GLA, gamolenska kiselina) je masna kiselina koja je prvenstveno zastupljena u biljnim uljima. Ona se prodaje kao prehrambeni suplement za tretiranje problema sa inflamacijom i autoimunskim bolestima, mada je njena efikasnost osporavana.^[5]

Hemija uredi

GLA je kategorisana kao n−6 (takođe se naziva ω−6 ili omega-6) masna kiselina, jer je prva dvostruka veza na metil kraju (označenom sa n ili ω) na šestoj vezi.^[6] U fiziološkoj literaturi, GLA se označava kao 18:3 (n−6). GLA je karboksilna kiselina sa 18-ugljenika dugim lancom i sa tri cis dvostruke veze. Ona je izomer α-linoleinske kiseline, koja je polinezasićena n−3 (omega-3) masna kiselina.

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Donald Voet, Judith G. Voet (2005). Biochemistry (3 izd.). Wiley. ISBN 978-0-471-19350-0.
↑ Clayden Jonathan, Nick Greeves, Stuart Warren, Peter Wothers (2001). Organic chemistry. Oxford, Oxfordshire: Oxford University Press. ISBN 0-19-850346-6.

Literatura uredi

Spoljašnje veze uredi

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[VoetBiochemistry3rd-5] Donald Voet, Judith G. Voet (2005). Biochemistry (3 izd.). Wiley. ISBN 978-0-471-19350-0.

[Clayden1st-6] Clayden Jonathan, Nick Greeves, Stuart Warren, Peter Wothers (2001). Organic chemistry. Oxford, Oxfordshire: Oxford University Press. ISBN 0-19-850346-6.

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