Dihidropirimidinaza
Dihidropirimidinaza (EC 3.5.2.2, hidantoinaza, hidropirimidinska hidraza, hidantoinska peptidaza, pirimidinska hidraza, D-hidantoinaza) je enzim sa sistematskim imenom 5,6-dihidropirimidin amidohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dihidropirimidinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.2.2 | ||||||||
| CAS broj | 9030-74-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 5,6-dihidrouracil + H2O 3-ureidopropanoat
Ovaj enzim takođe deluje na dihidrotimin i hidantoin.
Reference uredi
- ↑ Brooks, K.P., Jones, E.A., Kim, B.-D. and Sander, E.G. (1983). „Bovine liver dihydropyrimidine amidohydrolase: purification, properties, and characterization as a zinc metalloenzyme”. Arch. Biochem. Biophys. 226: 469-483. PMID 6639068.
- ↑ Eadie, G.S., Bernheim, F. and Bernheim, J.L.C. (1949). „Metabolism of cytosine, thymidine, uracil and barbituric acid by bacterial enzymes”. J. Biol. Chem. 181: 449-458. PMID 15393763.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.