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Citohrom P450, familija 1, član A1

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Citohrom P450, familija 1, član A1 je protein[1] koji je kod ljudi kodiran CYP1A1 genom.[2] Ovaj protein je član citohrom P450 superfamilije enzima.[3]

Citohrom P450, familija 1, član A1‎‎
Identifikatori
SimboliCYP1A1; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Vanjski IDOMIM: 108330 MGI: 88588 HomoloGene: 68062 GeneCards: CYP1A1 Gene
EC broj1.14.14.1
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez154313076
EnsemblENSG00000140465ENSMUSG00000032315
UniProtP04798P00184
RefSeq (mRNA)NM_000499.3NM_001136059.2
RefSeq (protein)NP_000490.1NP_001129531.1
Lokacija (UCSC)Chr 15:
75.01 - 75.02 Mb		Chr 9:
57.55 - 57.55 Mb
PubMed pretraga[1][2]

Funkcija uredi

CYP1A1 učestvuje u fazi I ksenobiotičkog metabolizma. Jedan od njegovih supstrata je teofilin. Inhibitori ovog enzima su fluorohinoloni i makrolidi. On se može indukovati aromatičnim ugljovodonicima.[4]

Reference uredi

  1. ↑ Kawajiri K (1999). „CYP1A1”. IARC Scientific Publications (148): 159–72. PMID 10493257. 
  2. ↑ Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (2004). „Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants”. Pharmacogenetics 14 (1): 1–18. DOI:10.1097/00008571-200401000-00001. PMID 15128046. 
  3. ↑ Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). „Molecular genetics of the human cytochrome P450 monooxygenase superfamily”. Xenobiotica 28 (12): 1129–65. DOI:10.1080/004982598238868. PMID 9890157. 
  4. ↑ Beresford AP (1993). „CYP1A1: friend or foe?”. Drug Metabolism Reviews 25 (4): 503–17. DOI:10.3109/03602539308993984. PMID 8313840. 

Literatura uredi

  • Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). „Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.”. Pharmacogenetics 14 (1): 1–18. DOI:10.1097/00008571-200401000-00001. PMID 15128046. 
  • Masson LF, Sharp L, Cotton SC, Little J (2005). „Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review.”. American Journal of Epidemiology 161 (10): 901–15. DOI:10.1093/aje/kwi121. PMID 15870154. 
  • Hildebrandt AG, Schwarz D, Krusekopf S, et al. (2007). „Recalling P446. P4501A1 (CYP1A1) opting for clinical application.”. Drug Metabolism Reviews 39 (2-3): 323–41. DOI:10.1080/03602530701498026. PMID 17786624. 


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