Cirazolin je neselektivni agonist alfa-1 adrenergičkog receptora (α1-AR), i antagonist alfa-2 adrenergičkog receptora[5]. Smatra se da ova kombinacija osobina može da učini cirazolin efektivnim vazokonstriktorom[5].
| Cirazolin
|
|
| IUPAC ime
|
| |
|---|
| 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole |
|
| Identifikacija
|
| CAS registarski broj
|
59939-16-1
|
| PubChem[1][2]
|
2765
|
| ChemSpider[3]
|
2663  Y
|
| MeSH
|
cirazoline
|
| ChEMBL[4]
|
CHEMBL13852 Y
|
| IUPHAR ligand
|
515
|
| Jmol-3D slike
|
Slika 1
|
|
|---|
O(c1c(cccc1)C2CC2)CC/3=N/CCN\3 |
|
|
|---|
InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15) Y
Kod: YAORIDZYZDUZCM-UHFFFAOYSA-N Y
InChI=1/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
Kod: YAORIDZYZDUZCM-UHFFFAOYAV |
|
| Svojstva
|
| Molekulska formula
|
C13H16N2O
|
| Molarna masa
|
216.279
|
|
 Y (šta je ovo?)
(verifikuj)
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
|
| Infobox references
|
Za cirazolin je takođe pokazano da umanjuje unos hrane kod pacova, što je potencijalno posledica aktivacije alfa 1-adrenoceptora u paraventrikularnog jezgra u hipotalamusa[6].
Literatura
uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ 5,0 5,1 Ruffolo Jr, RR; Ruffolo and Waddell (1982). „Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist”. J Pharmacol Exp Ther. 222 (1): 29–36. PMID 6123592.
- ↑ Davies, BT; Davies BT, Wellman PJ (1992). „Effects on ingestive behavior in rats of the alpha 1-adrenoceptor agonist cirazoline”. Eur J Pharmacol. 210 (1): 11–16. DOI:10.1016/0014-2999(92)90645-K. PMID 1350985.
Spoljašnje veze
uredi
