3-Jodotironamin (T1AM) je endogeni tironamin. T1AM je ligand visokog afiniteta za trag amin-asocirani receptor TAAR1 (TAR1, TA1), nedavno otkriveni G protein spregnuti receptor.[2][3] T1AM je najpotentniji TAAR1 agonist do sada otkriven.[4] Aktivacija TAAR1 receptora T1AM ligandom dovodi do produkcije velikih količina cAMP-a. Taj efekat je spregnut sa sniženjem telesne temperature i srčanog izlaza.[5] T1AM je deo signalnog puta koji moduliše srčanu funkciju.[6]
3-Јodotironamin
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IUPAC ime
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4-[4-(2-Amino-etil)-2-jodo-fenoksi]-fenol |
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Drugi nazivi
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T1AM
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Identifikacija
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CAS registarski broj
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712349-95-6
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ChemSpider[1]
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8126125 Y
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Jmol-3D slike
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Slika 1 Slika 2
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OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1
Ic2cc(ccc2Oc1ccc(O)cc1)CCN |
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InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2 Y Kod: XIINYOJWNGOUPF-UHFFFAOYSA-N Y
InChI=1/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2 Kod: XIINYOJWNGOUPF-UHFFFAOYAJ |
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Svojstva
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Molekulska formula
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C14H14INO2
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Molarna masa
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355,17 g/mol
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Y (šta je ovo?)
(verifikuj)
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
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Infobox references
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- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D (2004). „3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone”. Nat. Med. 10 (6): 638–42. DOI:10.1038/nm1051. PMID 15146179.
- ↑ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T (2006). „Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues”. J. Med. Chem. 49 (3): 1101–12. DOI:10.1021/jm0505718. PMID 16451074.
- ↑ Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ (2005). „Alternate Pathways of Thyroid Hormone Metabolism”. Thyroid 15 (8): 943–958. DOI:10.1089/thy.2005.15.943. PMID 16131336.
- ↑ „New compound may act to keep thyroid activity in check”. Pristupljeno 30. 5. 2008.
- ↑ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. (2007). „Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function”. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21 (7): 1597–608. DOI:10.1096/fj.06-7474com. PMID 17284482.
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