Rfam – razlika između verzija

{{rut}}{{infobox biodatabase

|description = Rfam baza podataka providessadrži alignmentsmodele poravnanja, consensus secondary structureskonsenzusnih andsekundarnnih covariancestruktura modelsi forkovarijansi RNARNK familiesfamilija.

|scope = RNARNK familiesfamilije

|organism = allsvi

|center = [[EuropeanEvropski Bioinformaticsbioinformatički Instituteinstitut|EBI]]

|format = [[StockholmStokholmski format]]

|license = [[PublicJavno domainvlasništvo]]

'''Rfam''' je [[baza podataka]] containingkoja informationsadrži aboutinformacije o familijama [[nekodirajuća RNK|nekodirajućih RNK]] (ncRNAncRNK) familiesi anddrugih otherstrukturnih structured RNARNK elementselemenata. Ona It is anje [[annotatedAnotacija|anotirana]], baza podataka [[OpenSlobodni accesspristup (publishingizdavaštvo)|openotvorenog accesspristupa]] databasekoju originallyje developedoriginalno at therazvio [[Wellcome Trust Sanger Institute]] inu collaborationkolaboraciji withsa [[Janelia Farm Research Campus|Janelia Farm]],<ref name=Griffiths-Jones_2003>{{cite journal | author = Griffiths-Jones S, Bateman A, Marshall M, Khanna A, Eddy SR | title = Rfam: an RNA family database | journal = Nucleic Acids Res. | volume = 31 | issue = 1 | pages = 439–41 | year = 2003 | pmid = 12520045 | doi =10.1093/nar/gkg006 | pmc = 165453 }}</ref><ref name=Griffiths-Jones_2005>{{cite journal | author = Griffiths-Jones S, Moxon S, Marshall M, Khanna A, Eddy SR, Bateman A | title = Rfam: annotating non-coding RNAs in complete genomes | journal = Nucleic Acids Res. | volume = 33 | issue = Database issue | pages = D121–4 | year = 2005 | pmid = 15608160 | doi = 10.1093/nar/gki081 | pmc = 540035}}</ref><ref name="pmid18953034">{{cite journal |author=Gardner PP, Daub J, Tate JG, ''et al.'' |title=Rfam: updates to the RNA families database |journal=Nucleic Acids Research |volume= 37|issue= Database issue|pages= D136|date=October 2008 |pmid=18953034 |doi=10.1093/nar/gkn766 |url= |pmc=2686503}}</ref><ref name="pmid21062808">{{cite journal |author=Gardner PP, Daub J, Tate J, Moore BL, Osuch IH, Griffiths-Jones S, Finn RD, Nawrocki EP, Kolbe DL, Eddy SR, Bateman A |title=Rfam: Wikipedia, clans and the "decimal" release. |journal=Nucleic Acids Res |volume=39 |issue=Database issue |pages=D141–5 |year=2011 |pmid=21062808 |doi=10.1093/nar/gkq1129 |pmc=3013711}}</ref> andi currentlykoju hostedtrenutno at theodržava [[EuropeanEvropski Bioinformaticsbioinformatički Instituteinstitut]].<ref>{{cite web |publisher=Xfam Blog |title=Moving to xfam.org |url=http://xfam.wordpress.com/2014/05/01/moving-to-xfam-org/ |accessdate=3 May 2014}}</ref> Rfam isje designeddizajnirana tona besličan similarnačin to thesa [[Pfam]] databasebazom forpodataka annotatingza proteinanotaciju familiesproteinskih familija.

UnlikeZa razliku od [[proteinsprotein]]a, ncRNAsncRNK oftensekvence havečesto similarimaju slične [[RNASekundarna structurestruktura nukleinskih kiselina|secondarysekundarne structurestrukture]], withoutmada sharingnjihove muchprimarne similaritystrukture innisu the [[primary sequence]]slične. Rfam dividesdeli ncRNAsncRNK intosekvence familiesu basedfamilije onna evolutionbazi fromevolucije aiz commonzajedničlig ancestorpretka. Producing [[multiplePoravnavanje sequencevišestrukih alignmentsekvenci|Poravnavanja višestrukih sekvenci]]s (MSA) oftih thesefamilija familiesmože canda providepruži insightuvid intou theirnjihovou structurestrukturu andi functionfunkciju, similarkao što je to theslučaj casesa ofproteinskim protein familiesfamilijama. MSA Thesesu MSAspostale becomejoš morekorisnije usefuldodatkom withsekundarne the addition of secondary structure informationstrukture. Rfam researchersistraživači alsotakođe contributedoprinose tovikipedijinoj [[Wikipedia]]'sinicijativi: [[Wikipedia:WikiProject RNA|RNA WikiProject]].<ref name="pmid21062808"/><ref name="pmid18945806">{{cite journal |author=Daub J, Gardner PP, Tate J, ''et al.'' |title=The RNA WikiProject: Community annotation of RNA families |journal=RNA |volume= 14|issue= 12|pages= 2462–4|date=October 2008 |pmid=18945806 |doi=10.1261/rna.1200508 |url= |pmc=2590952}}</ref>