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[[FileDatoteka:Aptamer biotin.png|thumb|Struktura RNK aptamera specifičnog za [[biotin]]. Površina i osnova aptamera su prikazani žuto. Biotin (sfere) se dobro uklapa u šupljinu RNK površine]]
'''Aptameri''' (od {{jez-lat-lat|aptus}} - stati, i {{jez-grč-lat|meros}} - region) su [[oligonukleotid|oligonukleinske]] kiseline ili [[peptid]]ni molekuli koji se vezuju za specifični ciljni molekul. Prirodni aptameri postoje kao [[riboprekidač]]i. U laboratoriji se aptameri opično formiraju selekcijom iz velikog mnoštva randomnih sekvenci. Aptameri nalaze primenu u baznim istraživanjima, a koriste se i za kliničke svrhe kao makromolekulski lekovi. Aptameri se mogu kombinovati sa [[ribozim]]ima radi samostalnog presecanja u prisustvu ciljnog molekula.
 
== Literatura ==
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* {{cite journal |author=Ellington AD, Szostak JW |title=In vitro selection of RNA molecules that bind specific ligands |journal=Nature |volume=346 |issue=6287 |pages=818–22 |year=1990 |month=Aug |pmid=1697402 |doi=10.1038/346818a0 }}
* {{cite journal |author=Bock LC, Griffin LC, Latham JA, Vermaas EH, Toole JJ |title=Selection of single-stranded DNA molecules that bind and inhibit human thrombin |journal=Nature |volume=355 |issue=6360 |pages=564–6 |year=1992 |month=Feb |pmid=1741036 |doi=10.1038/355564a0 }}
* {{cite journal |author=Hoppe-Seyler F, Butz K |title=Peptide aptamers: powerful new tools for molecular medicine |journal=J Mol Med. |volume=78 |issue=8 |pages=426–30 |year=2000 |pmid=11097111 |url=http://link.springer.de/link/service/journals/00109/bibs/0078008/00780426.htm |doi=10.1007/s001090000140}}
* {{cite journal |author=Carothers JM, Oestreich SC, Davis JH, Szostak JW |title=Informational complexity and functional activity of RNA structures |journal=J Am Chem Soc. |volume=126 |issue=16 |pages=5130–7 |year=2004 |month=Apr |pmid=15099096 |doi=10.1021/ja031504a }}
* {{cite journal |author=Cohen BA, Colas P, Brent R |title=An artificial cell-cycle inhibitor isolated from a combinatorial library |journal=Proc Natl Acad Sci USA. |volume=95 |issue=24 |pages=14272–7 |year=1998 |month=Nov |pmid=9826690 |pmc=24363 |url=http://www.pnas.org/cgi/pmidlookup?view=long&pmid=9826690 |doi=10.1073/pnas.95.24.14272}}
* {{cite journal |author=Binkowski BF, Miller RA, Belshaw PJ |title=Ligand-regulated peptides: a general approach for modulating protein-peptide interactions with small molecules |journal=Chem Biol. |volume=12 |issue=7 |pages=847–55 |year=2005 |month=Jul |pmid=16039531 |doi=10.1016/j.chembiol.2005.05.021 }}
* {{cite journal |author=Sullenger BA, Gilboa E |title=Emerging clinical applications of RNA |journal=Nature |volume=418 |issue=6894 |pages=252–8 |year=2002 |month=Jul |pmid=12110902 |doi=10.1038/418252a }}
* {{cite journal |author=Ng EW, Shima DT, Calias P, Cunningham ET, Guyer DR, Adamis AP |title=Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease |journal=Nat Rev Drug Discov |volume=5 |issue=2 |pages=123–32 |year=2006 |month=Feb |pmid=16518379 |doi=10.1038/nrd1955 }}
* {{cite journal |author=Drabovich AP, Berezovski M, Okhonin V, Krylov SN |title=Selection of smart aptamers by methods of kinetic capillary electrophoresis |journal=Anal Chem. |volume=78 |issue=9 |pages=3171–8 |year=2006 |month=May |pmid=16643010 |doi=10.1021/ac060144h }}
* {{cite journal |author=Cho EJ, Lee JW, Ellington, AD |title=Applications of Aptamers as Sensors |journal=Annual Review of Analytical Chemistry |volume=2 |issue=1 |pages=241–64 |year=2009 |pmid=20636061 |url=http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.anchem.1.031207.112851 |doi=10.1146/annurev.anchem.1.031207.112851}}
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* [http://aptamer.freebase.com Aptamerska baza]
* [http://immunet.cn/mimodb MimoDB baza podataka]
 
 
[[Kategorija:Nukleinske kiseline]]
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