Piracetam
Piracetam je nootropni lek. Njegovo hemijsko ime je 2-okso-1-pirolidin acetamid. On ima zajedničku 2-okso-pirolidonsku strukturu sa 2-okso-pirolidin karboksilnom kiselinom (piroglutamatom). Piracetam je ciklični GABA derivat. On pripada grupi racetama. Piracetam se koristi za mioklonus.[6][7]
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| (IUPAC) ime | |||
|---|---|---|---|
| 2-okso-1-pirolidineacetamid | |||
| Klinički podaci | |||
| Robne marke | Breinox, Dinagen, Lucetam, Nootropil, Nootropyl, Oikamid, i mnoga druga | ||
| AHFS/Drugs.com | Internacionalno ime leka | ||
| Identifikatori | |||
| CAS broj | 7491-74-9 | ||
| ATC kod | N06BX03 | ||
| PubChem[1][2] | 4843 | ||
| ChemSpider[3] | 4677 | ||
| UNII | ZH516LNZ10 
| ||
| KEGG[4] | D01914
| ||
| ChEMBL[5] | CHEMBL36715
| ||
| Hemijski podaci | |||
| Formula | C6H10N2O2 | ||
| Mol. masa | 142,156 | ||
| SMILES | eMolekuli & PubHem | ||
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| Farmakokinetički podaci | |||
| Bioraspoloživost | ~100% | ||
| Poluvreme eliminacije | 4 - 5 sata | ||
| Izlučivanje | Urinarno | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | POM (UK) | ||
| Način primene | Oralno i parenteralno | ||
Popularna trgovačka imena piracetama u Evropi su Nootropil i Lucetam, između ostalih.
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ „Nootropil”. NetDoctor.co.uk. 8. 7. 2004.. Pristupljeno 21. 9. 2009.
- ↑ UCB Pharma Limited (2005). „Nootropil 800 mg & 1200 mg Tablets and Solution”. electronic Medicines Compendium. Datapharm Communications. Arhivirano iz originala na datum 2006-12-07. Pristupljeno 8. 12. 2005.
