Peptidilamidoglikolatna lijaza
Peptidilamidoglikolatna lijaza (EC 4.3.2.5, alfa-hidroksiglicin amidujuća dealkilaza, peptidilna-alfa-hidroksiglicin alfa-amidujuća lijaza, HGAD, PGL, PAL, peptidilnaamidoglikolat peptidilnaamid-lijaza) je enzim sa sistematskim imenom peptidilamidoglikolat peptidil-amid-lijaza (formira glioksilat).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Peptidilamidoglikolatna lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.2.5 | ||||||||
| CAS broj | 131689-50-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- peptidilamidoglikolat peptidilni amid + glioksilat
Ovaj enzim deluje produkat reakcije koji katalizuje enzim EC 1.14.17.3.
Reference uredi
- ↑ Katapodis, A.G., Ping, D. and May, S.W. (1990). „A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of α-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine α-amidating monooxygenase in peptide amidation”. Biochemistry 29: 6115-6120. PMID 2207061.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.