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Peptid YY

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Peptid YY je kratak (36-aminokiselina) protein koga oslobađaju ćelije ileuma i debelo crevo u responsu na unos hrane. Kod ljudi on umanjuje apetit. On je takođe poznat kao PYY, peptid tirozin tirozin, ili pankreasni peptid YY3-36.[1]

Peptid YY

PDB prikaz baziran na 1qbf.
Dostupne strukture
1qbf, 1ru5, 1ruu, 2dez, 2df0
Identifikatori
SimboliPYY; PYY1
Vanjski IDOMIM: 600781 MGI: 99924 HomoloGene: 3066 GeneCards: PYY Gene
Ortolozi
VrstaČovekMiš
Entrez5697217212
EnsemblENSG00000131096ENSMUSG00000017311
UniProtP10082Q3V334
RefSeq (mRNA)NM_004160NM_145435
RefSeq (protein)NP_004151NP_663410
Lokacija (UCSC)Chr 17:
39.39 - 39.44 Mb		Chr 11:
101.92 - 101.92 Mb
PubMed pretraga[1][2]

StrukturaUredi

Peptid YY je srodan sa pankreasnom peptidnom familijom, jer je 18 od njegovih 36 aminokiselina locirano u istim pozicijama kao kod pankreasnog peptida.[2] Postoje dve glavne forme peptide YY: PYY1-36 i PYY3-36 koji imaju PP strukturni motiv. Međutim, najčešća forma cirkulišućeg PYY je PYY3-36, koja se vezuje za Y2 receptor (Y2R) Y familije receptora.[3] Peptid YY3-36 (PYY) je linearni polipeptid koji se sastoji od 36 aminokiselina.

Vidi jošUredi

ReferenceUredi

  1. ↑ "Entrez Gene: PYY peptide YY". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5697. 
  2. ↑ DeGroot, Leslie Jacob (1989). J. E. McGuigan. ur. Endocrinology. Philadelphia: Saunders. str. 2754. ISBN 0-7216-2888-5. 
  3. ↑ Murphy KG, Bloom SR (December 2006). "Gut hormones and the regulation of energy homeostasis". Nature 444 (7121): 854–9. PMID 17167473. doi:10.1038/nature05484. 

LiteraturaUredi

  • Ekblad E, Sundler F (2002). "Distribution of pancreatic polypeptide and peptide YY.". Peptides 23 (2): 251–61. PMID 11825640. doi:10.1016/S0196-9781(01)00601-5. 
  • Sandström O, El-Salhy M (2002). "Ontogeny and the effect of aging on pancreatic polypeptide and peptide YY.". Peptides 23 (2): 263–7. PMID 11825641. doi:10.1016/S0196-9781(01)00603-9. 
  • Yang H (2002). "Central and peripheral regulation of gastric acid secretion by peptide YY.". Peptides 23 (2): 349–58. PMID 11825649. doi:10.1016/S0196-9781(01)00611-8. 
  • Naruse S, Kitagawa M, Ishiguro H, Hayakawa T (2002). "Feedback regulation of pancreatic secretion by peptide YY.". Peptides 23 (2): 359–65. PMID 11825650. doi:10.1016/S0196-9781(01)00612-X. 
  • Aponte GW (2002). "PYY-mediated fatty acid induced intestinal differentiation.". Peptides 23 (2): 367–76. PMID 11825651. doi:10.1016/S0196-9781(01)00613-1. 
  • Hagan MM (2002). "Peptide YY: a key mediator of orexigenic behavior.". Peptides 23 (2): 377–82. PMID 11825652. doi:10.1016/S0196-9781(01)00614-3. 
  • Mannon PJ (2002). "Peptide YY as a growth factor for intestinal epithelium.". Peptides 23 (2): 383–8. PMID 11825653. doi:10.1016/S0196-9781(01)00615-5. 
  • Tseng WW, Liu CD (2002). "Peptide YY and cancer: current findings and potential clinical applications.". Peptides 23 (2): 389–95. PMID 11825654. doi:10.1016/S0196-9781(01)00616-7. 
  • El-Salhy M, Suhr O, Danielsson A (2002). "Peptide YY in gastrointestinal disorders.". Peptides 23 (2): 397–402. PMID 11825655. doi:10.1016/S0196-9781(01)00617-9. 
  • Imamura M (2002). "Effects of surgical manipulation of the intestine on peptide YY and its physiology.". Peptides 23 (2): 403–7. PMID 11825656. doi:10.1016/S0196-9781(01)00618-0. 
  • Beglinger C, Degen L (2007). "Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY?". Physiol. Behav. 89 (4): 460–4. PMID 16828127. doi:10.1016/j.physbeh.2006.05.048. 
  • Eberlein GA, Eysselein VE, Schaeffer M et al. (1989). "A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36).". Peptides 10 (4): 797–803. PMID 2587421. doi:10.1016/0196-9781(89)90116-2. 
  • Facer P, Bishop AE, Cole GA et al. (1989). "Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells.". Gastroenterology 97 (1): 48–57. PMID 2721879. 
  • Tatemoto K, Nakano I, Makk G et al. (1989). "Isolation and primary structure of human peptide YY.". Biochem. Biophys. Res. Commun. 157 (2): 713–7. PMID 3202875. doi:10.1016/S0006-291X(88)80308-5. 
  • Lukinius AI, Ericsson JL, Lundqvist MK, Wilander EM (1986). "Ultrastructural localization of serotonin and polypeptide YY (PYY) in endocrine cells of the human rectum.". J. Histochem. Cytochem. 34 (6): 719–26. PMID 3517149. 
  • Adrian TE, Ferri GL, Bacarese-Hamilton AJ et al. (1985). "Human distribution and release of a putative new gut hormone, peptide YY.". Gastroenterology 89 (5): 1070–7. PMID 3840109. 
  • Lundell I, Blomqvist AG, Berglund MM et al. (1996). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.". J. Biol. Chem. 270 (49): 29123–8. PMID 7493937. doi:10.1074/jbc.270.49.29123. 
  • Bard JA, Walker MW, Branchek TA, Weinshank RL (1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.". J. Biol. Chem. 270 (45): 26762–5. PMID 7592911. doi:10.1074/jbc.270.45.26762. 
  • Hort Y, Baker E, Sutherland GR et al. (1995). "Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1.". Genomics 26 (1): 77–83. PMID 7782089. doi:10.1016/0888-7543(95)80085-Z. 
  • Kohri K, Nata K, Yonekura H et al. (1993). "Cloning and structural determination of human peptide YY cDNA and gene.". Biochim. Biophys. Acta 1173 (3): 345–9. PMID 8318545. 
  • Batterham RL, Heffron H, Kapoor S, Chivers J, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD, Withers DJ (2006). "Critical role for peptide YY in protein-mediated satiation and body-weight regulation.". Cell Metabolism 4 (3): 223–233. PMID 16950139. doi:10.1016/j.cmet.2006.08.001. 
  • DeGroot, Leslie Jacob (1989). J. E. McGuigan. ur. Endocrinology. Philadelphia: Saunders. 

Spoljašnje vezeUredi

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