Peptid YY
edit |
Peptid YY je kratak (36-aminokiselina) protein koga oslobađaju ćelije ileuma i debelo crevo u responsu na unos hrane. Kod ljudi on umanjuje apetit. On je takođe poznat kao PYY, peptid tirozin tirozin, ili pankreasni peptid YY3-36.[1]
Peptid YY | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
![]() PDB prikaz baziran na 1qbf. | |||||||||||
Dostupne strukture | |||||||||||
1qbf, 1ru5, 1ruu, 2dez, 2df0 | |||||||||||
Identifikatori | |||||||||||
Simboli | PYY; PYY1 | ||||||||||
Vanjski ID | OMIM: 600781 MGI: 99924 HomoloGene: 3066 GeneCards: PYY Gene | ||||||||||
| |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 5697 | 217212 | |||||||||
Ensembl | ENSG00000131096 | ENSMUSG00000017311 | |||||||||
UniProt | P10082 | Q3V334 | |||||||||
RefSeq (mRNA) | NM_004160 | NM_145435 | |||||||||
RefSeq (protein) | NP_004151 | NP_663410 | |||||||||
Lokacija (UCSC) | Chr 17: 39.39 - 39.44 Mb | Chr 11: 101.92 - 101.92 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Sadržaj/Садржај
StrukturaUredi
Peptid YY je srodan sa pankreasnom peptidnom familijom, jer je 18 od njegovih 36 aminokiselina locirano u istim pozicijama kao kod pankreasnog peptida.[2] Postoje dve glavne forme peptide YY: PYY1-36 i PYY3-36 koji imaju PP strukturni motiv. Međutim, najčešća forma cirkulišućeg PYY je PYY3-36, koja se vezuje za Y2 receptor (Y2R) Y familije receptora.[3] Peptid YY3-36 (PYY) je linearni polipeptid koji se sastoji od 36 aminokiselina.
Vidi jošUredi
ReferenceUredi
- ↑ "Entrez Gene: PYY peptide YY". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5697.
- ↑ DeGroot, Leslie Jacob (1989). J. E. McGuigan. ur. Endocrinology. Philadelphia: Saunders. str. 2754. ISBN 0-7216-2888-5.
- ↑ Murphy KG, Bloom SR (December 2006). "Gut hormones and the regulation of energy homeostasis". Nature 444 (7121): 854–9. PMID 17167473. doi:10.1038/nature05484.
LiteraturaUredi
- Ekblad E, Sundler F (2002). "Distribution of pancreatic polypeptide and peptide YY.". Peptides 23 (2): 251–61. PMID 11825640. doi:10.1016/S0196-9781(01)00601-5.
- Sandström O, El-Salhy M (2002). "Ontogeny and the effect of aging on pancreatic polypeptide and peptide YY.". Peptides 23 (2): 263–7. PMID 11825641. doi:10.1016/S0196-9781(01)00603-9.
- Yang H (2002). "Central and peripheral regulation of gastric acid secretion by peptide YY.". Peptides 23 (2): 349–58. PMID 11825649. doi:10.1016/S0196-9781(01)00611-8.
- Naruse S, Kitagawa M, Ishiguro H, Hayakawa T (2002). "Feedback regulation of pancreatic secretion by peptide YY.". Peptides 23 (2): 359–65. PMID 11825650. doi:10.1016/S0196-9781(01)00612-X.
- Aponte GW (2002). "PYY-mediated fatty acid induced intestinal differentiation.". Peptides 23 (2): 367–76. PMID 11825651. doi:10.1016/S0196-9781(01)00613-1.
- Hagan MM (2002). "Peptide YY: a key mediator of orexigenic behavior.". Peptides 23 (2): 377–82. PMID 11825652. doi:10.1016/S0196-9781(01)00614-3.
- Mannon PJ (2002). "Peptide YY as a growth factor for intestinal epithelium.". Peptides 23 (2): 383–8. PMID 11825653. doi:10.1016/S0196-9781(01)00615-5.
- Tseng WW, Liu CD (2002). "Peptide YY and cancer: current findings and potential clinical applications.". Peptides 23 (2): 389–95. PMID 11825654. doi:10.1016/S0196-9781(01)00616-7.
- El-Salhy M, Suhr O, Danielsson A (2002). "Peptide YY in gastrointestinal disorders.". Peptides 23 (2): 397–402. PMID 11825655. doi:10.1016/S0196-9781(01)00617-9.
- Imamura M (2002). "Effects of surgical manipulation of the intestine on peptide YY and its physiology.". Peptides 23 (2): 403–7. PMID 11825656. doi:10.1016/S0196-9781(01)00618-0.
- Beglinger C, Degen L (2007). "Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY?". Physiol. Behav. 89 (4): 460–4. PMID 16828127. doi:10.1016/j.physbeh.2006.05.048.
- Eberlein GA, Eysselein VE, Schaeffer M et al. (1989). "A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36).". Peptides 10 (4): 797–803. PMID 2587421. doi:10.1016/0196-9781(89)90116-2.
- Facer P, Bishop AE, Cole GA et al. (1989). "Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells.". Gastroenterology 97 (1): 48–57. PMID 2721879.
- Tatemoto K, Nakano I, Makk G et al. (1989). "Isolation and primary structure of human peptide YY.". Biochem. Biophys. Res. Commun. 157 (2): 713–7. PMID 3202875. doi:10.1016/S0006-291X(88)80308-5.
- Lukinius AI, Ericsson JL, Lundqvist MK, Wilander EM (1986). "Ultrastructural localization of serotonin and polypeptide YY (PYY) in endocrine cells of the human rectum.". J. Histochem. Cytochem. 34 (6): 719–26. PMID 3517149.
- Adrian TE, Ferri GL, Bacarese-Hamilton AJ et al. (1985). "Human distribution and release of a putative new gut hormone, peptide YY.". Gastroenterology 89 (5): 1070–7. PMID 3840109.
- Lundell I, Blomqvist AG, Berglund MM et al. (1996). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.". J. Biol. Chem. 270 (49): 29123–8. PMID 7493937. doi:10.1074/jbc.270.49.29123.
- Bard JA, Walker MW, Branchek TA, Weinshank RL (1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.". J. Biol. Chem. 270 (45): 26762–5. PMID 7592911. doi:10.1074/jbc.270.45.26762.
- Hort Y, Baker E, Sutherland GR et al. (1995). "Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1.". Genomics 26 (1): 77–83. PMID 7782089. doi:10.1016/0888-7543(95)80085-Z.
- Kohri K, Nata K, Yonekura H et al. (1993). "Cloning and structural determination of human peptide YY cDNA and gene.". Biochim. Biophys. Acta 1173 (3): 345–9. PMID 8318545.
- Batterham RL, Heffron H, Kapoor S, Chivers J, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD, Withers DJ (2006). "Critical role for peptide YY in protein-mediated satiation and body-weight regulation.". Cell Metabolism 4 (3): 223–233. PMID 16950139. doi:10.1016/j.cmet.2006.08.001.
- DeGroot, Leslie Jacob (1989). J. E. McGuigan. ur. Endocrinology. Philadelphia: Saunders.