Penicilamin (3-merkapto-D-valin) je najkarakterističniji degradacioni produkt penicilinskih antibiotika. On se koristi kao antireumatski i helacini agens za Vilsonovu bolest.[3][4][5][6][7][8][9]
Penicilamin
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| (IUPAC) ime
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| 2-amino-3-metil-3-fulfanilbutanoinska kiselina
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| Klinički podaci
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| Robne marke
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Artamine, Cuprenil, Cuprimine, Cupripen
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| AHFS/Drugs.com
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Monografija
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| Identifikatori
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| CAS broj
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52-67-5
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| ATC kod
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M01CC01
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| DrugBank
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DB00859
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| KEGG[1]
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C07418  Y
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| ChEMBL[2]
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CHEMBL50868 Y
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| Hemijski podaci
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| Formula
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C5H11NO2S
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| Mol. masa
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149.211
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)
Key: VVNCNSJFMMFHPL-UHFFFAOYSA-N Y |
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| Fizički podaci
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| Tačka topljenja
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198.5 °C (389 °F)
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| Farmakokinetički podaci
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| Poluvreme eliminacije
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1 sad
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| Izlučivanje
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Renalno, uglavno u obliku disulfida.
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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| Način primene
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Oralno
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- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ WALSHE JM: Penicillamine, a new oral therapy for Wilson's disease. Am J Med. 1956 Oct;21(4):487-95. PMID 13362281
- ↑ Walshe JM: The story of penicillamine: a difficult birth. Mov Disord. 2003 Aug;18(8):853-9. PMID 12889074
- ↑ Gong Y, Frederiksen SL, Gluud C: D-penicillamine for primary biliary cirrhosis. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004789. PMID 15495127
- ↑ Suarez-Almazor ME, Spooner C, Belseck E: Penicillamine for rheumatoid arthritis. Cochrane Database Syst Rev. 2000;(2):CD001460. PMID 10796440
- ↑ Munro R, Capell HA: Penicillamine. Br J Rheumatol. 1997 Jan;36(1):104-9. PMID 9117147
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.
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