PTK7
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Receptor sličan tirozinskoj proteinskoj kinazi 7 je enzim koji je kod ljudi kodiran PTK7 genom.[1][2]
| Protein tirozinske kinaze 7 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | PTK7; CCK-4; CCK4 | ||||||||||
| Vanjski ID | OMIM: 601890 MGI: 1918711 HomoloGene: 43672 GeneCards: PTK7 Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5754 | 71461 | |||||||||
| Ensembl | ENSG00000112655 | ENSMUSG00000023972 | |||||||||
| UniProt | Q13308 | Q8BKG3 | |||||||||
| Ref. Sekv. (iRNK) | NM_001270398 | NM_175168 | |||||||||
| Ref. Sekv. (protein) | NP_001257327 | NP_780377 | |||||||||
| Lokacija (UCSC) | Chr 6: 43.04 - 43.13 Mb | Chr 17: 46.56 - 46.63 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptorske proteinske tirozinske kinaze prenose ekstracelularne signale kroz ćelijsku membranu. Jednoj podgrupi tih kinaza nedostaje primetna katalitička aktivnost tirozinske kinaze, mada zadržavaju ulogu u prenosu signala. Protein kodiran ovim genom ima intracelularni domen koji je hologan sa tirozinskim kinazama. Smatra se da on deluje kao ćelijski adhezioni molekul. Ovaj gen se izražava u karcinomima debelog creva, a nije prisutan u normalnim ćelijama debelog creva, i stoga je jedan od markera progresije tumora. Poznate su četiri transkriptne varijante koje kodiraju četiri različite izoforme.[2]
Reference uredi
Literatura uredi
- Lee ST, Strunk KM, Spritz RA (1993). „A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.”. Oncogene 8 (12): 3403–10. PMID 8247543.
- Park SK, Lee HS, Lee ST (1997). „Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.”. J. Biochem. 119 (2): 235–9. DOI:10.1093/oxfordjournals.jbchem.a021228. PMID 8882711.
- Banga SS, Ozer HL, Park SK, Lee ST (1997). „Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to human chromosome 6p21.1→p12.2 by fluorescence in situ hybridization.”. Cytogenet. Cell Genet. 76 (1–2): 43–4. DOI:10.1159/000134511. PMID 9154124.
- Jung JW, Ji AR, Lee J i dr.. (2003). „Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA”. Biochim. Biophys. Acta 1579 (2–3): 153–63. DOI:10.1016/s0167-4781(02)00536-5. PMID 12427550.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). „Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry”. Nat. Biotechnol. 21 (6): 660–6. DOI:10.1038/nbt827. PMID 12754519.
- Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Kobus FJ, Fleming KG (2005). „The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions”. Biochemistry 44 (5): 1464–70. DOI:10.1021/bi048076l. PMID 15683231.
- Katoh M, Katoh M (2007). „Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells”. Int. J. Mol. Med. 20 (3): 405–9. DOI:10.3892/ijmm.20.3.405. PMID 17671748.