3',5'-Ciklični-AMP fosfodiestaraza
(Preusmjereno sa stranice PDE1)
3',5'-Ciklični-AMP fosfodiestaraza (EC 3.1.4.53, cAMP-specifična fosfodiesteraza, cAMP-specifična PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) je enzim sa sistematskim imenom 3',5'-ciklična-AMP 5'-nukleotidohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3',5'-Ciklični-AMP fosfodiestaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.4.53 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- adenozin 3',5'-ciklična fosfat + H2O AMP
Za dejstvo ovog enzim je neophodan jon Mg2+ ili Mn2+.
Reference uredi
- ↑ Alonso, G.D., Schoijet, A.C., Torres, H.N. and Flawiá, M.M. (2006). „TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi”. Mol. Biochem. Parasitol. 145: 40-49. PMID 16225937.
- ↑ Bader, S., Kortholt, A., Snippe, H. and Van Haastert, P.J. (2006). „DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells”. J. Biol. Chem. 281: 20018-20026. PMID 16644729.
- ↑ Rascón, A., Soderling, S.H., Schaefer, J.B. and Beavo, J.A. (2002). „Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei”. Proc. Natl. Acad. Sci. USA 99: 4714-4719. PMID 11930017.
- ↑ Johner, A., Kunz, S., Linder, M., Shakur, Y. and Seebeck, T. (2006). „Cyclic nucleotide specific phosphodiesterases of Leishmania major”. BMC Microbiol. 6: #25-25. PMID 16522215.
- ↑ Lugnier, C., Keravis, T., Le Bec, A., Pauvert, O., Proteau, S. and Rousseau, E. (1999). „Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei”. Biochim. Biophys. Acta 1472: 431-446. PMID 10564757.
- ↑ Imamura, R., Yamanaka, K., Ogura, T., Hiraga, S., Fujita, N., Ishihama, A. and Niki, H. (1996). „Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli”. J. Biol. Chem. 271: 25423-25429. PMID 8810311.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.