P2RY13
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P2Y purinoceptor 13 je protein koji je kod ljudi kodiran P2RY13 genom.[1][2][3]
| Purinski receptor P2Y, G-protein spregnuti, 13 | |||||
|---|---|---|---|---|---|
| Identifikatori | |||||
| Simboli | P2RY13; GPCR1; FKSG77; GPR86; GPR94; P2Y13; SP174 | ||||
| Vanjski ID | OMIM: 606380 MGI: 1921441 HomoloGene: 12543 IUPHAR: P2Y13 GeneCards: P2RY13 Gene | ||||
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| Pregled RNK izražavanja | |||||
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| podaci | |||||
| Ortolozi | |||||
| Vrsta | Čovek | Miš | |||
| Entrez | 53829 | 74191 | |||
| Ensembl | ENSG00000181631 | ENSMUSG00000036362 | |||
| UniProt | Q9BPV8 | Q0VF10 | |||
| RefSeq (mRNA) | NM_023914 | NM_028808 | |||
| RefSeq (protein) | NP_076403 | NP_083084 | |||
| Lokacija (UCSC) | Chr 3: 152.53 - 152.53 Mb | Chr 3: 59.3 - 59.3 Mb | |||
| PubMed pretraga | [1] | [2] | |||
Proizvod ovog gena, P2Y13, je član familije G-protein spregnutih receptora. Ova familija ima nekoliko tipova receptora sa različitom farmakološkom selektivnosti za razne adenozinske i uridinske nukleotide. Oni se preklapaju u nekim slučajevima. Endogeni ligand ovog receptora je ADP. Dve transkriptne varijante koje kodiraju isti protein su poznate.[3]
Vidi još uredi
Reference uredi
- ↑ Wittenberger T, Schaller HC, Hellebrand S (Mar 2001). „An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors”. J Mol Biol 307 (3): 799–813. DOI:10.1006/jmbi.2001.4520. PMID 11273702.
- ↑ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). „Discovery and mapping of ten novel G protein-coupled receptor genes”. Gene 275 (1): 83–91. DOI:10.1016/S0378-1119(01)00651-5. PMID 11574155.
- ↑ 3,0 3,1 „Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13”.
Literatura uredi
- Communi D, Gonzalez NS, Detheux M, et al. (2001). „Identification of a novel human ADP receptor coupled to G(i).”. J. Biol. Chem. 276 (44): 41479–85. DOI:10.1074/jbc.M105912200. PMID 11546776.
- Zhang FL, Luo L, Gustafson E, et al. (2002). „P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse.”. J. Pharmacol. Exp. Ther. 301 (2): 705–13. DOI:10.1124/jpet.301.2.705. PMID 11961076.
- Takeda S, Kadowaki S, Haga T, et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”. FEBS Lett. 520 (1–3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Spoljašnje veze uredi
- „P2Y Receptors: P2Y13”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.