P2RY11
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P2RY11 (P2Y purinoceptor 11) je protein je protein koji je kod ljudi kodiran P2RY11 genom.[1][2]
| Purinski receptor P2Y, G-protein spregnuti, 11 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | P2RY11; P2Y11 | ||||||||||
| Vanjski ID | OMIM: 602697 IUPHAR: P2Y11 GeneCards: P2RY11 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5032 | n/a | |||||||||
| Ensembl | ENSG00000176130 | n/a | |||||||||
| UniProt | Q96G91 | n/a | |||||||||
| RefSeq (mRNA) | NM_002566 | n/a | |||||||||
| RefSeq (protein) | NP_002557 | n/a | |||||||||
| Lokacija (UCSC) | Chr 19: 10.08 - 10.09 Mb | n/a | |||||||||
| PubMed pretraga | [1] | n/a | |||||||||
Protein kodiran ovim genom pripada familiji G-protein spregnutih receptora, koji su preferentno aktivirani nukleotidima adenozina i uridina. Ovaj receptor je spregnut sa stimulacijom puteva fosfoinozitida i adenilil ciklaze i ponaša se kao selektivni purinoceptor. Postoje prirodni združeni transkripti, koji nastaju intergenskim splajsovanjem ovog gena i neposredno prethodećeg gena (PPAN, koji kodira petar pan homolog). PPAN-P2RY11 iRNK je široko izražena i kodira fuzioni protein koji ima zajednički identitet individualnih genskih proizvoda.[2]
Vidi još uredi
Reference uredi
- ↑ Communi D, Govaerts C, Parmentier M, Boeynaems JM (Jan 1998). „Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase”. J Biol Chem 272 (51): 31969–73. DOI:10.1074/jbc.272.51.31969. PMID 9405388.
- ↑ 2,0 2,1 „Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11”.
Literatura uredi
- van der Weyden L, Conigrave AD, Morris MB (2000). „Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor.”. Immunol. Cell Biol. 78 (4): 369–74. DOI:10.1046/j.1440-1711.2000.00918.x. PMID 10947861.
- Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). „Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.” (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098.
- Communi D, Suarez-Huerta N, Dussossoy D, et al. (2001). „Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes.”. J. Biol. Chem. 276 (19): 16561–6. DOI:10.1074/jbc.M009609200. PMID 11278528.
- Moore DJ, Chambers JK, Wahlin JP, et al. (2001). „Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.”. Biochim. Biophys. Acta 1521 (1-3): 107–19. PMID 11690642.
- Duhant X, Schandené L, Bruyns C, et al. (2002). „Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes.”. J. Immunol. 169 (1): 15–21. PMID 12077223.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Moreschi I, Bruzzone S, Nicholas RA, et al. (2006). „Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.”. J. Biol. Chem. 281 (42): 31419–29. DOI:10.1074/jbc.M606625200. PMID 16926152.
- Zylberg J, Ecke D, Fischer B, Reiser G (2007). „Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis.”. Biochem. J. 405 (2): 277–86. DOI:10.1042/BJ20061728. PMC 1904521. PMID 17338680.
Spoljašnje veze uredi
- „P2Y Receptors: P2Y11”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.