Opiorfin

Opiorfin
	(2S,5S,8S,11S,14S)-14,17-diamino-8-benzyl-2,11-bis(3-guanidinopropyl)-5-(hydroxymethyl)-4,7,10,13,17-pentaoxo-3,6,9,12-tetraazaheptadecan-1-oic acid
Drugi nazivi	Gln-Arg-Phe-Ser-Arg
Identifikacija
CAS registarski broj	864084-88-8
Jmol-3D slike	Slika 1
SMILES
	O=C([C@H](CO)NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)N)=O)=O)=O)N[C@H](C(O)=O)CCCNC(N)=N
Svojstva
Molekulska formula	C29H48N12O8
Molarna masa	692.77 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Opiorfin je endogeno hemijsko jedinjenje koje je prvo izolovano iz ljudske pljuvačke. Inicijalna istraživanja na miševima su pokazala da ovo jedinjenje ima veći analgetski efekat od morfina.

Opiorfin deluje putem zaustavljanja normalnog razlaganja prirodnih analgetskih opioida u kičmenoj moždini, zvanih enkefalini. On je relativno mali peptid koji se sastoji od pet aminokiselina: Gln-Arg-Phe-Ser-Arg.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

Opiorfin pentapetid potiče od N-terminalnog regiona proteina PROL1 (prolinom bogat, lakrimal 1).^[1] Opiorfin inhibira dve proteaze: neutralnu ekto-endopeptidazu (MME) i ekto-aminopeptidazu N (ANPEP).^[1]

Vidi još uredi

RB-101

Literatura uredi

↑ ^1,0 ^1,1 ^1,2 Dickinson DP, Thiesse M (April 1996). „cDNA cloning of an abundant human lacrimal gland mRNA encoding a novel tear protein”. Curr. Eye Res. 15 (4): 377–86. PMID 8670737.
↑ Andy Coghlan (November 13, 2006). „Natural-born painkiller found in human saliva”. New Scientist.
↑ „Natural chemical 'beats morphine'”. BBC News. November 14, 2006.
↑ Mary Beckman (November 13, 2006). „Prolonging Painkillers”. Science. Arhivirano iz originala na datum 2007-12-12. Pristupljeno 2014-04-08.
↑ Stanovic S, Boranic M, Petrovecki M, Batinic D, Skodlar J, Nemet D, Labar B. Haematologia. 2000; 30(1):1-10.
↑ Thanawala V, Kadam VJ, Ghosh R (October 2008). „Enkephalinase inhibitors: potential agents for the management of pain”. Current Drug Targets 9 (10): 887–94. DOI:10.2174/138945008785909356. PMID 18855623.
↑ Davies KP (March 2009). „The role of opiorphins (endogenous neutral endopeptidase inhibitors) in urogenital smooth muscle biology”. The Journal of Sexual Medicine 6 Suppl 3: 286–91. DOI:10.1111/j.1743-6109.2008.01186.x. PMC 2864530. PMID 19267851.
↑ Tian XZ, Chen J, Xiong W, He T, Chen Q (July 2009). „Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice”. Peptides 30 (7): 1348–54. DOI:10.1016/j.peptides.2009.04.002. PMID 19442408.

Spoljašnje veze uredi

Portal Hemija

[pmid8670737-1] 1,0 ^1,1 ^1,2 Dickinson DP, Thiesse M (April 1996). „cDNA cloning of an abundant human lacrimal gland mRNA encoding a novel tear protein”. Curr. Eye Res. 15 (4): 377–86. PMID 8670737.

[2] Andy Coghlan (November 13, 2006). „Natural-born painkiller found in human saliva”. New Scientist.

[3] „Natural chemical 'beats morphine'”. BBC News. November 14, 2006.

[4] Mary Beckman (November 13, 2006). „Prolonging Painkillers”. Science. Arhivirano iz originala na datum 2007-12-12. Pristupljeno 2014-04-08.

[5] Stanovic S, Boranic M, Petrovecki M, Batinic D, Skodlar J, Nemet D, Labar B. Haematologia. 2000; 30(1):1-10.

[pmid18855623-6] Thanawala V, Kadam VJ, Ghosh R (October 2008). „Enkephalinase inhibitors: potential agents for the management of pain”. Current Drug Targets 9 (10): 887–94. DOI:10.2174/138945008785909356. PMID 18855623.

[pmid19267851-7] Davies KP (March 2009). „The role of opiorphins (endogenous neutral endopeptidase inhibitors) in urogenital smooth muscle biology”. The Journal of Sexual Medicine 6 Suppl 3: 286–91. DOI:10.1111/j.1743-6109.2008.01186.x. PMC 2864530. PMID 19267851.

[pmid19442408-8] Tian XZ, Chen J, Xiong W, He T, Chen Q (July 2009). „Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice”. Peptides 30 (7): 1348–54. DOI:10.1016/j.peptides.2009.04.002. PMID 19442408.

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