Oktopamin

Oktopamin
(IUPAC) ime
	(RS)-4-(2-amino-1-hidroksi-etil)fenol
Klinički podaci
Identifikatori
CAS broj	104-14-3
ATC kod	C01CA18
PubChem	4581
ChemSpider	4420
UNII	14O50WS8JD
ChEBI	CHEBI:17134
ChEMBL	CHEMBL53929
Hemijski podaci
Formula	C8H11NO2
Mol. masa	153,178 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C8H11NO2/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4,8,10-11H,5,9H2 ; Key: QHGUCRYDKWKLMG-UHFFFAOYSA-N
Sinonimi	Norsimpatol, Norsinefrin, para-oktopamin, beta-hidroksitiramin, para-hidroksi-fenil-etanolamin
Farmakokinetički podaci
Poluvreme eliminacije	15 Minuta u insektima
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno

Oktopamin (β,4-dihidroksifenetilamin) je endogeni biogeni amin koji je blisko srodan sa norepinefrinom, i utiče na adrenergični i dopaminergični sistem. On se prirodno javlja u mnogim biljkama, uključujući gorku pomorandžu.^[5]^[6] Biosinteza D-(–)-enantiomera oktopamina je β-hidroksilacija tiramina enzimom dopamin β-hidroksilaza. Pod tržišnim imenima Epirenor, Norden, i Norfen, oktopamin se takoše koristi kao simpatomimetički agens.^[7]^[8]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Tang, F; Tao, L; Luo, X; Ding, L; Guo, M; Nie, L; Yao, S (2006). „Determination of octopamine, synephrine and tyramine in Citrus herbs by ionic liquid improved 'green' chromatography”. Journal of chromatography. A 1125 (2): 182–8. DOI:10.1016/j.chroma.2006.05.049. PMID 16781718.
↑ Jagiełło-Wójtowicz E (1979). „Mechanism of central action of octopamine”. Pol J Pharmacol Pharm 31 (5): 509–16. PMID 121158.
↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
↑ „Pharmacognosy And Pharmacobiotechnology - Google Books”.

Literatura uredi

Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
P.D. Evans, "Octopamine", in Comprehensive Insect Physiology, 11, 499, Oxford University Press 1985.

Vidi još uredi

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Tang, F; Tao, L; Luo, X; Ding, L; Guo, M; Nie, L; Yao, S (2006). „Determination of octopamine, synephrine and tyramine in Citrus herbs by ionic liquid improved 'green' chromatography”. Journal of chromatography. A 1125 (2): 182–8. DOI:10.1016/j.chroma.2006.05.049. PMID 16781718.

[pmid121158-6] Jagiełło-Wójtowicz E (1979). „Mechanism of central action of octopamine”. Pol J Pharmacol Pharm 31 (5): 509–16. PMID 121158.

[isbn3-88763-075-0-7] Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.

[urlPharmacognosy_And_Pharmacobiotechnology_-_Google_Books-8] „Pharmacognosy And Pharmacobiotechnology - Google Books”.

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