Purinska nukleozidaza

(Preusmjereno sa Nukleozidaza)

Purinska nukleozidaza (EC 3.2.2.1, nukleozidaza, purin beta-ribozidaza, purin nukleozidna hidrolaza, purinska ribonukleozidaza, ribonukleozidna hidrolaza, nukleozidna hidrolaza, N-ribozil purinska ribohidrolaza, nukleozidaza g, N-D-ribozilpurinska ribohidrolaza, inozin-adenozin-guanozin preferentna nukleozidna hidrolaza, purin-specifična nukleozidna N-ribohidrolaza, IAG-nukleozidna hidrolaza, IAG-NH) je enzim sa sistematskim imenom purin-nukleozidna ribohidrolaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

Purinska nukleozidaza
3t8i.jpg
Purinska nukleozidaza tetramer, Saccharolobus solfataricus
Identifikatori
EC broj 3.2.2.1
CAS broj 9025-44-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
purinski nukleozid + H2O D-riboza + purinska baza

Enzim iz bakterije Ochrobactrum anthropi specifično katalizuje ireverzibilnu N-ribozidnu hidrolizu purinskih nukleozida.

ReferenceUredi

  1. Heppel, L.A. and Hilmoe, R.J. (1952). "Phosphorolysis and hydrolysis of purine ribosides from yeast". J. Biol. Chem. 198: 683-694. PMID 12999785. 
  2. Kalckar, H.M. (1951). "Biosynthetic aspects of nucleosides and nucleic acids". Pubbl. Staz. Zool. (Napoli) 23: 87-103. 
  3. Takagi, Y. and Horecker, B.L. (1956). "Purification and properties of a bacterial riboside hydrolyase". J. Biol. Chem. 225: 77-86. PMID 13416219. 
  4. Tarr, H.L.A. (1955). "Fish muscle riboside hydrolases". Biochem. J. 59: 386-391. PMID 14363106. 
  5. Parkin, D.W. (1996). "Purine-specific nucleoside N-ribohydrolase from 'Trypanosoma brucei brucei. Purification, specificity, and kinetic mechanism". J. Biol. Chem. 271: 21713-21719. PMID 8702965. 
  6. Ogawa, J., Takeda, S., Xie, S.X., Hatanaka, H., Ashikari, T., Amachi, T. and Shimizu, S. (2001). "Purification, characterization, and gene cloning of purine nucleosidase from Ochrobactrum anthropi". Appl. Environ. Microbiol. 67: 1783-1787. PMID 11282633. 
  7. Versées, W., Decanniere, K., Van Holsbeke, E., Devroede, N. and Steyaert, J. (2002). "Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax". J. Biol. Chem. 277: 15938-15946. PMID 11854281. 
  8. Mazumder-Shivakumar, D. and Bruice, T.C. (2005). "Computational study of IAG-nucleoside hydrolase: determination of the preferred ground state conformation and the role of active site residues". Biochemistry 44: 7805-7817. PMID 15909995. 

LiteraturaUredi

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