Neurotrofni moždani faktor
| edit |
Neurotrofni moždani faktor (BDNF) je sekretorni protein[2] koji je kod ljudi kodiran BDNF genom.[3][4] BDNF je član neurotrofinske familije faktora rasta, koja je srodna sa kanoničkim „nervnim faktorima rasta“, NGF. Neurotrofinski faktori su prisutni u mozgu i u perifernom nervnom sistemu.
| Neurotrofni moždani faktor | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB prikaz baziran na 1bnd[1]. | |||||||||||
| Dostupne strukture | |||||||||||
| 1B8M, 1BND | |||||||||||
| Identifikatori | |||||||||||
| Simboli | BDNF; ANON2; BULN2 | ||||||||||
| Vanjski ID | OMIM: 113505 MGI: 88145 HomoloGene: 7245 GeneCards: BDNF Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 627 | 12064 | |||||||||
| Ensembl | ENSG00000176697 | ENSMUSG00000048482 | |||||||||
| UniProt | P23560 | P21237 | |||||||||
| RefSeq (mRNA) | NM_001143805.1 | NM_001048139.1 | |||||||||
| RefSeq (protein) | NP_001137277.1 | NP_001041604.1 | |||||||||
| Lokacija (UCSC) | Chr 11: 27.68 - 27.74 Mb | Chr 2: 109.67 - 109.73 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Reference uredi
- ↑ Robinson, R. C.; Radziejewski, C.; Stuart, D. I.; Jones, E. Y. (1995). „Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer”. Biochemistry 34 (13): 4139–4146. DOI:10.1021/bi00013a001. PMID 7703225.
- ↑ Binder DK, Scharfman HE (September 2004). „Brain-derived Neurotrophic Factor”. Growth Factors 22 (3): 123–31. DOI:10.1080/08977190410001723308. PMC 2504526. PMID 15518235.
- ↑ Jones KR, Reichardt LF (October 1990). „Molecular cloning of a human gene that is a member of the nerve growth factor family”. Proc. Natl. Acad. Sci. U.S.A. 87 (20): 8060–4. Bibcode 1990PNAS...87.8060J. DOI:10.1073/pnas.87.20.8060. PMC 54892. PMID 2236018.
- ↑ Maisonpierre PC, Le Beau MM, Espinosa R, Ip NY, Belluscio L, de la Monte SM, Squinto S, Furth ME, Yancopoulos GD (July 1991). „Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations”. Genomics 10 (3): 558–68. PMID 1889806.
Spoljašnje veze uredi
- Cotman CW, Berchtold NC (28. 01. 2004.). „BDNF and Alzheimer's Disease—What's the Connection?”. Alzforum: Live Discussions. Alzheimer Research Forum. Arhivirano iz originala na datum 2008-10-11. Pristupljeno 21. 08. 2008.
- Patten-Hitt E (14. 06. 2001.). „Brain-Derived Neurotrophic Factor (BDNF)”. Sciencexpress. The HDLighthouse, Huntingtons Disease: Information and Community. Arhivirano iz originala na datum 2008-07-25. Pristupljeno 21. 08. 2008.
- Highfield R (18. 10. 2007.). „Brain scans 'could reveal mental strength'”. Science. Telegraph.co.uk. Arhivirano iz originala na datum 2008-05-31. Pristupljeno 21. 08. 2008. »Low BDNF activity promotes resilience«