NAD(P)H oksidaza

NAD(P)H oksidaza
Identifikatori
EC broj	1.6.3.1
CAS broj	77106-92-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

NAD(P)H oksidaza (EC 1.6.3.1, THOX2, ThOX, dualna oksidaza, p138tox, tiroid NADPH oksidaza, tiroidna oksidaza, tiroidna oksidaza 2, NADPH oksidaza) je enzim sa sistematskim imenom NAD(P)H:kiseonik oksidoreduktaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

NAD(P)H + H⁺ + O₂

\rightleftharpoons

NAD(P)⁺ +H₂O₂

Za rad ovog enzima je neophodan FAD, hem i kalcijum.

Reference uredi

↑ Moreno, J.C., Bikker, H., Kempers, M.J., van Trotsenburg, A.S., Baas, F., de Vijlder, J.J., Vulsma, T. and Ris-Stalpers, C. (2002). „Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism”. N. Engl. J. Med. 347: 95-102. PMID 12110737.
↑ De Deken, X., Wang, D., Dumont, J.E. and Miot, F. (2002). „Characterization of ThOX proteins as components of the thyroid H₂O₂-generating system”. Exp. Cell 273: 187-196. PMID 11822874.
↑ De Deken, X., Wang, D., Many, M.C., Costagliola, S., Libert, F., Vassart, G., Dumont, J.E. and Miot, F. (2000). „Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family”. J. Biol. Chem. 275: 23227-23233. PMID 10806195.
↑ Dupuy, C., Ohayon, R., Valent, A., Noel-Hudson, M.S., Deme, D. and Virion, A. (1999). „Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs”. J. Biol. Chem. 274: 37265-37269. PMID 10601291.
↑ Leseney, A.M., Deme, D., Legue, O., Ohayon, R., Chanson, P., Sales, J.P., Pires de Carvalho, D., Dupuy, C. and Virion, A. (1999). „Biochemical characterization of a Ca²⁺/NAD(P)H-dependent H₂O₂ generator in human thyroid tissue”. Biochimie 81: 373-380. PMID 10401672.
↑ Dupuy, C., Virion, A., Ohayon, R., Kaniewski, J., Deme, D. and Pommier, J. (1991). „Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane”. J. Biol. Chem. 266: 3739-3743. PMID 1995628.

Literatura uredi

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze uredi

MeSH NAD(P)H+oxidase

[1] Moreno, J.C., Bikker, H., Kempers, M.J., van Trotsenburg, A.S., Baas, F., de Vijlder, J.J., Vulsma, T. and Ris-Stalpers, C. (2002). „Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism”. N. Engl. J. Med. 347: 95-102. PMID 12110737.

[2] De Deken, X., Wang, D., Dumont, J.E. and Miot, F. (2002). „Characterization of ThOX proteins as components of the thyroid H₂O₂-generating system”. Exp. Cell 273: 187-196. PMID 11822874.

[3] De Deken, X., Wang, D., Many, M.C., Costagliola, S., Libert, F., Vassart, G., Dumont, J.E. and Miot, F. (2000). „Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family”. J. Biol. Chem. 275: 23227-23233. PMID 10806195.

[4] Dupuy, C., Ohayon, R., Valent, A., Noel-Hudson, M.S., Deme, D. and Virion, A. (1999). „Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs”. J. Biol. Chem. 274: 37265-37269. PMID 10601291.

[5] Leseney, A.M., Deme, D., Legue, O., Ohayon, R., Chanson, P., Sales, J.P., Pires de Carvalho, D., Dupuy, C. and Virion, A. (1999). „Biochemical characterization of a Ca²⁺/NAD(P)H-dependent H₂O₂ generator in human thyroid tissue”. Biochimie 81: 373-380. PMID 10401672.

[6] Dupuy, C., Virion, A., Ohayon, R., Kaniewski, J., Deme, D. and Pommier, J. (1991). „Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane”. J. Biol. Chem. 266: 3739-3743. PMID 1995628.

[1]

[2]

[3]

[4]

[5]

[6]