Metoksamin

Metoksamin
(IUPAC) ime
	2-amino-1-(2,5-dimetoksifenil)propan-1-ol
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	390-28-3
ATC kod	C01CA10
PubChem	6082
DrugBank	DB00723
ChemSpider	5857
UNII	HUQ1KC1YLI
KEGG	D08201
ChEMBL	CHEMBL524
Hemijski podaci
Formula	C11H17NO3
Mol. masa	211,258
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3 ; Key: WJAJPNHVVFWKKL-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Metoksamin je α₁-agonist adrenergičkog receptora,^[6] koji ima sličnu strukturu sa fenilefrinom i 2,5-DMA. Ovo jedinjenje je razvijeno tokom 1940-tih.^[7] Ovaj lek indukuje vazokonstrikciju kože i crevnih krvnih sudova, čime se povećava periferni vaskularni otpor i povišava arterijski krvni pritisak. Zbog njegovog hipertenzivnog dejstva, on može da izazove kompenzatorni refleks bradikardije putem baroreceptora.

Vidi još uredi

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Pazdernik, Thomas L.; Kerecsen, Laszlo (2007) [2003] „5” Goljan, Edward F. (Paperback) Pharmacology Rapid Review (Second izd.) Philadelphia, PA: Mosby-Elsevier str. 39 ISBN 978-0-323-04550-6. Pristupljeno 17 Apr 2010
↑ US Patent 2359707 - DIMETHOXYPHENYL beta-HYDROXY ISOPROPYLAMINE

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Pazdernik, Thomas L.; Kerecsen, Laszlo (2007) [2003] „5” Goljan, Edward F. (Paperback) Pharmacology Rapid Review (Second izd.) Philadelphia, PA: Mosby-Elsevier str. 39 ISBN 978-0-323-04550-6. Pristupljeno 17 Apr 2010

[7] US Patent 2359707 - DIMETHOXYPHENYL beta-HYDROXY ISOPROPYLAMINE

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