Metilkobalamin

Metilkobalamin
(IUPAC) ime
	karbanid; kobalt(3+);
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	13422-55-4
ATC kod	B03BA05
PubChem	6436232
UNII	BR1SN1JS2W
ChEMBL	CHEMBL1697757
Hemijski podaci
Formula	C63H91CoN13O14P
Mol. masa	1344,40 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;-1;+3/p-2 ; Key: ZFLASALABLFSNM-UHFFFAOYSA-L
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	oralno, sublingualno, injekcija.

Metilkobalamin (mekobalamin, MeCbl, ili MeB₁₂) je kobalamin koji se koristi u tretmanu periferne neuropatije, dijabetičke neuropatije, i kao preliminarni tretman za amiotrofičnu lateralnu sklerozu. On je forma vitamina B₁₂ i razlikuje se od cijanokobalamina po tome što je cijanid zamenjen metil grupom.^[4] Metilkobalamin poseduje oktaedralni centar kobalta(III). Metilkobalamin se može dobiti u obliku svetlih crvenih kristala.^[5]

Iz perspektive koordinacione hemije, metilkobalamin je osoben po tome što je redak primer enzima koji sadrži metal-alkil veze. Nikal-metil intermedijeri su predloženi kao mogući završni korak metanogeneze.

Produkcija uredi

Metilkobalamin se može formirati u laboratoriji redukcijom cijanokobalamina sa natrijum borohidridom u alkalnom rastvoru, i naknadnom adicijom metil jodida.^[5]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ L. R. McDowell, Vitamins in animal and human nutrition
↑ ^5,0 ^5,1 David Dophin (1971). „Preparation of the Reduced Forms of Vitamin B₁₂ and of Some Analogs of the Vitamin B₁₂ Coenzyme Containing a Cobalt-Carbon Bond”. D.B. McCormick and L.D. Wright, Eds Vol. XVIII: 34-54.

Vidi još uredi

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[4] L. R. McDowell, Vitamins in animal and human nutrition

[MechB12-5] 5,0 ^5,1 David Dophin (1971). „Preparation of the Reduced Forms of Vitamin B₁₂ and of Some Analogs of the Vitamin B₁₂ Coenzyme Containing a Cobalt-Carbon Bond”. D.B. McCormick and L.D. Wright, Eds Vol. XVIII: 34-54.

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