Metilisani-DNK—(protein)-cistein S-metiltransferaza
Metilisani-DNK—(protein)-cistein S-metiltransferaza (EC 2.1.1.63, Methylated-DNA---(protein)-cysteine S-methyltransferase) je enzim sa sistematskim imenom DNK-6-O-metilguanin:(protein)-L-cistein S-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Metilisani-DNK—(protein)-cistein S-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.63 | ||||||||
| CAS broj | 77271-19-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- DNK (koja sadrži 6-O-metilguanin) + protein L-cistein DNK (bez 6-O-metilguanina) + protein S-metil-L-cistein
Ovaj protein učestvuje u popravci alkilisanog DNK. On deluje na alkilisani DNK (cf. EC 3.2.2.20, DNK-3-metiladenin glikozidaza I i EC 3.2.2.21, DNK-3-metiladenin glikozidaza II).
Reference uredi
- ↑ Foote, R.S., Mitra, S. and Pal, B.C. (1980). „Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli”. Biochem. Biophys. Res. Commun. 97: 654-659. PMID 7008792.
- ↑ Olsson, M. and Lindehl, T. (1980). „Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue”. J. Biol. Chem. 255: 10569-10571. PMID 7000780.
- ↑ Pegg, A.E. and Byers, T.L. (1992). „Repair of DNA containing O6-alkylguanine”. FASEB J. 6: 2302-2310. PMID 1544541.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.