Metilisana-tiol-koenzim M metiltransferaza
Metilisana-tiol-koenzim M metiltransferaza (EC 2.1.1.251, mtsA (gen)) je enzim sa sistematskim imenom metilated-tiol:koenzim M metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Metilisana-tiol-koenzim M metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.251 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- metantiol + koenzim M metil-KoM + vodonik sulfid (sveukupna reakcija)
- (1a) metantiol + [Co(I) metilisani-tiol-specifični korinoidni protein] [metil-Co(III) metilisani-tiol-specifični korinoidni protein] + vodonik sulfid
- (1b) [metil-Co(III) metilisani-tiol-specifični korinoidni protein] + koenzim M metil-KoM + [Co(I) metilisani-tiol-specifični korinoidni protein]
Ovaj enzim učestvuje u metanogenezi metilisanih tiola, poput metan tiola, dimetil sulfida, i 3-S-metilmerkaptopropionata.
Reference uredi
- ↑ Paul, L. and Krzycki, J.A. (1996). „Sequence and transcript analysis of a novel Methanosarcina barkeri methyltransferase II homolog and its associated corrinoid protein homologous to methionine synthase”. J. Bacteriol. 178: 6599-6607. PMID 8932317.
- ↑ Tallant, T.C. and Krzycki, J.A. (1997). „Methylthiol:coenzyme M methyltransferase from Methanosarcina barkeri, an enzyme of methanogenesis from dimethylsulfide and methylmercaptopropionate”. J. Bacteriol. 179: 6902-6911. PMID 9371433.
- ↑ Tallant, T.C., Paul, L. and Krzycki, J.A. (2001). „The MtsA subunit of the methylthiol:coenzyme M methyltransferase of Methanosarcina barkeri catalyses both half-reactions of corrinoid-dependent dimethylsulfide: coenzyme M methyl transfer”. J. Biol. Chem. 276: 4485-4493. PMID 11073950.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.