Metil aminolevulinat

Metil aminolevulinat (MAL, Metviks) je prolek koji se metaboliše do protoporfirina IX. On se koristi u fotodinamičkoj terapiji. Metviks krema se primenjuje topikalno.

Metil aminolevulinat
(IUPAC) ime
metil 5-amino-4-okso-pentanoat
Klinički podaci
AHFS/Drugs.com Multum, informacije za potrošače
Identifikatori
CAS broj 33320-16-0
ATC kod L01XD03
PubChem[1][2] 16052023
DrugBank DB00992
ChemSpider[3] 13180320
ChEMBL[4] CHEMBL1096562 DaY
Hemijski podaci
Formula C6H11NO3 
Mol. masa 145,156 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Odobrenja i indikacijeUredi

Metil aminolevulinat je odobren u mnogim zemljama za tretman nemelanomnog raka kože.[5] Ovaj lek je odobren u Novom Zelandu za tretmant karcinoma bazalnih ćelija.[6]

On ima izvesne prednosti u odnosu na Levulan.[7]

ReferenceUredi

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. "New 5 Year Metvix-PDT Data Demonstrate Long-Term Efficacy & Reliability For NM Skin Cancer Treatment" 2006[mrtav link]
  6. "Methyl aminolevulinate photodynamic therapy (MAL PDT)"
  7. Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009 by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T

Spoljašnje vezeUredi


Šablon:Intracelularni hemoterapijski agensi

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