Melatoninski receptor 1A

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Melatoninski receptor tip 1A je protein koji je kod ljudi kodiran MTNR1A genom.

Melatoninski receptor 1A
Identifikatori
Simboli	MTNR1A; MEL-1A-R; MT1
Vanjski ID	OMIM: 600665 MGI: 102967 HomoloGene: 21207 IUPHAR: MT1 GeneCards: MTNR1A Gene
Ontologija gena Molekularna funkcija • aktivnost prenosa signala • receptorska aktivnost • aktivnost G-protein spregnutog receptor • aktivnost melatoninskog receptora Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • G-proteinska signalizacija, spregnuta sa cikličnim nukleotidnim sekundarnim glasnikom • cirkadijanski ritam
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	4543	17773
Ensembl	ENSG00000168412	ENSMUSG00000054764
UniProt	P48039	Q61184
RefSeq (mRNA)	NM_005958.3	NM_008639.2
RefSeq (protein)	NP_005949.1	NP_032665.1
Lokacija (UCSC)	Chr 4: 187.35 - 187.48 Mb	Chr 8: 46.15 - 46.17 Mb
PubMed pretraga	[1]	[2]

MT₁ protein je jedan od dva receptora sa visokim afinitetom za melatonin, koji je primarni hormon epifize. Ovaj receptor je G protein spregnuti 7-transmembranski receptor koji je odgovoran za dejstvo melatonina na sisarski cirkadijanski ritam i reproduktivne promene na koje utiče dužina dana. Ovaj receptor je integralni membranski protein koji je lociran u dva specifična moždana regiona. Hipotalamusno suprahiazmatično jedro učestvuju u cirkadijanskom ritmu, dok je hipofizni pars tuberalis odgovoran za reproduktivne efekte melatonina.

Literatura

• Brzezinski A; Brzezinski, Amnon (1997). „Melatonin in humans”. N. Engl. J. Med. 336 (3): 186–95. DOI:10.1056/NEJM199701163360306. PMID 8988899. 
• Khan AU, Olson DL (1975). „Physical therapy and exercise-induced bronchospasm”. Physical therapy 55 (8): 878–81. PMID 1144527. 
• Reppert SM, Weaver DR, Ebisawa T (1994). „Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses”. Neuron 13 (5): 1177–85. DOI:10.1016/0896-6273(94)90055-8. PMID 7946354. 
• Witt-Enderby PA, Dubocovich ML (1996). „Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells”. Mol. Pharmacol. 50 (1): 166–74. PMID 8700109. 
• Witt-Enderby PA, Masana MI, Dubocovich ML (1998). „Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor”. Endocrinology 139 (7): 3064–71. DOI:10.1210/en.139.7.3064. PMID 9645677. 
• Ebisawa T, Kajimura N, Uchiyama M i dr.. (1999). „Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders”. Biochem. Biophys. Res. Commun. 262 (3): 832–7. DOI:10.1006/bbrc.1999.1308. PMID 10471411. 
• Brydon L, Roka F, Petit L i dr.. (2000). „Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins”. Mol. Endocrinol. 13 (12): 2025–38. DOI:10.1210/me.13.12.2025. PMID 10598579. 
• Niles LP, Wang J, Shen L i dr.. (2000). „Melatonin receptor mRNA expression in human granulosa cells”. Mol. Cell. Endocrinol. 156 (1–2): 107–10. DOI:10.1016/S0303-7207(99)00135-5. PMID 10612428. 
• Song CK, Bartness TJ (2001). „CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity”. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2): R666–72. PMID 11448873. 
• Roy D, Angelini NL, Fujieda H i dr.. (2001). „Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin”. Endocrinology 142 (11): 4711–20. DOI:10.1210/en.142.11.4711. PMID 11606436. 
• Savaskan E, Olivieri G, Meier F i dr.. (2002). „Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients”. J. Pineal Res. 32 (1): 59–62. DOI:10.1034/j.1600-079x.2002.00841.x. PMID 11841602. 
• Savaskan E, Wirz-Justice A, Olivieri G i dr.. (2002). „Distribution of melatonin MT1 receptor immunoreactivity in human retina”. J. Histochem. Cytochem. 50 (4): 519–26. PMID 11897804. 
• Ayoub MA, Couturier C, Lucas-Meunier E i dr.. (2002). „Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer”. J. Biol. Chem. 277 (24): 21522–8. DOI:10.1074/jbc.M200729200. PMID 11940583. 
• Yuan L, Collins AR, Dai J i dr.. (2003). „MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells”. Mol. Cell. Endocrinol. 192 (1–2): 147–56. DOI:10.1016/S0303-7207(02)00029-1. PMID 12088876. 
• Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Slominski A, Pisarchik A, Zbytek B i dr.. (2003). „Functional activity of serotoninergic and melatoninergic systems expressed in the skin”. J. Cell. Physiol. 196 (1): 144–53. DOI:10.1002/jcp.10287. PMID 12767050. 
• Morcuende JA, Minhas R, Dolan L i dr.. (2004). „Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis”. Spine 28 (17): 2025–8; discussion 2029. DOI:10.1097/01.BRS.0000083235.74593.49. PMID 12973153. 
• Aust S, Thalhammer T, Humpeler S i dr.. (2004). „The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia”. J. Pineal Res. 36 (1): 43–8. DOI:10.1046/j.1600-079X.2003.00095.x. PMID 14675129. 

Vidi još

• Melatoninski receptor

Spoljašnje veze

• „Melatonin Receptors: MT₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.