Otvori glavni meni

Levonorgestrel (L-norgestrel ili D-norgestrel) (Plan B, Postinor[6]) je druga generacija sintetičkih progestogena. On se koristi kao aktivni sastojaku u pojedinim hormonalnim kontraceptivima, uključujući kombinovane oralne kontraceptivne pilule, pilule progestogena, pilule za hitnu kontracepciju, intrauterinske sisteme, kontraceptivne implante, i terapiju hormonske zamene.

Levonorgestrel
(IUPAC) ime
(–)-13-etil-17-etinil-17-hidroksi- 1,2,6,7,8,9,10,11,12,13,14,15,16, 17- tetradekahidrociklopenta[a] fenantren-3-on
Klinički podaci
Robne marke Norplant
MedlinePlus a610021
Identifikatori
CAS broj 797-63-7
ATC kod G03AC03 G03AD01
PubChem[1][2] 13109
DrugBank DB00367
ChemSpider[3] 12560
UNII 5W7SIA7YZW YesY
KEGG[4] D00950 YesY
ChEBI CHEBI:6443 YesY
ChEMBL[5] CHEMBL1389 YesY
Hemijski podaci
Formula C21H28O2 
Mol. masa 312,446 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost ~100%
Vezivanje za proteine plazme 55%
Metabolizam Hepatički putem CYP3A4
Poluvreme eliminacije 36 ± 13 h
Izlučivanje Renal: 45%; Fekalno:32%
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Rx-OTC
Način primene Implant, oralno

ReferenceUredi

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Oral contraceptives that can be used for emergency contraception

Spoljašnje vezeUredi