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Levonordefrin

Levonordefrin (Nordefrin, Neo-kobefrin, α-metilnorepinefrin, α-Me-NE) je simpatomimetički amin koji se koristi kao topikalno nazalni dekongestiv i vazokonstriktor u stomatologiji.[6] On je takođe metabolit antihipertenzivnog leka metildope, i ima kritičnu ulogu u njegovoj farmakologiji i terapetskom dejstvu.

Levonordefrin
(IUPAC) ime
4-[(1R,2S)-2-amino-1-hidroksipropil]benzen-1,2-diol
Klinički podaci
Identifikatori
CAS broj 829-74-3
ATC kod nije dodeljen
PubChem[1][2] 164739
DrugBank DB06707
ChemSpider[3] 144416
UNII V008L6478D DaY
KEGG[4] D02388 DaY
ChEMBL[5] CHEMBL677 DaY
Hemijski podaci
Formula C9H13NO3 
Mol. masa 183,204 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status ℞ Prescription only

Reference uredi

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. ↑ Prescribing information for COOK-WAITE Carbocaine 2% with Neo-Cobefrin[mrtav link] Carestream Health, Inc.

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