Laktaza
Laktaza (EC 3.2.1.108, laktaza-florizinska hidrolaza) je enzim sa sistematskim imenom laktoza galaktohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Laktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Tetramer laktaze (E. coli) | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.2.1.108 | ||||||||
| CAS broj | 2604851 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Enzim iz intestinalne sluznice je izolovan kao kompleks koji takođe katalizuje reakciju enzima EC 3.2.1.62, glikozilkeramidaza.
Reference uredi
- ↑ Lorenz-Meyer, H., Blum, A.L., Haemmerli, H.P. and Semenza, G. (1972). „A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase”. Eur. J. Clin. Invest. 2: 326-331. PMID 5082068.
- ↑ Ramaswamay, S. and Radhakrishnan, A.N. (1975). „Lactase-phlorizin hydrolase complex from monkey small intestine. Purification, properties and evidence for two catalytic sites”. Biochim. Biophys. Acta 403: 446-455. PMID 810166.
- ↑ Schlegel-Haueter, S., Hore, P., Kerry, K.R. and Semenza, G. (1972). „The preparation of lactase and glucoamylase of rat small intestine”. Biochim. Biophys. Acta 258: 506-519. PMID 5010299.
- ↑ Skovbjerg, H., Norén, O., Sjöström, H., Danielsen, E.M. and Enevoldsen, B.S. (1982). „Further characterization of intestinal lactase/phlorizin hydrolase”. Biochim. Biophys. Acta 707: 89-97. PMID 6814489.
- ↑ Skovbjerg, H., Sjöström, H. and Norén, O. (1981). „Purification and characterization of amphiphilic lactase-phlorizin hydrolase from human small-intestine”. Eur. J. Biochem. 114: 653-661. PMID 6786877.
- ↑ Asp, N.G., Dahlqvist, A. and Koldovský, O. (1969). „Human small-intestinal β-galactosidases. Separation and characterization of one lactase and one hetero β-galactosidase”. Biochem. J. 114: 351-359. PMID 5822067.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.