LPAR5
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LPA5, receptor lizofosfatidne kiseline 5, je protein koji je kod čoveka kodiran LPAR5 gena.[1][2][3][4][5] LPA5 je G protein-spregnuti receptor koji vezuje lipidni signalni molekul lizofosfatidnu kiselinu (LPA).[6]
| Receptor lizofosfatidne kiseline 5 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | LPAR5; GPR92 ; GPR93; KPG_010; LPA5 | ||||||||||
| Vanjski ID | OMIM: 606926 MGI: 2685918 HomoloGene: 10696 IUPHAR: GeneCards: LPAR5 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 57121 | 381810 | |||||||||
| Ensembl | ENSG00000184574 | ENSMUSG00000067714 | |||||||||
| UniProt | Q9H1C0 | n/a | |||||||||
| RefSeq (mRNA) | NM_020400 | XM_355812 | |||||||||
| RefSeq (protein) | NP_065133 | XP_355812 | |||||||||
| Lokacija (UCSC) | Chr 12: 6.6 - 6.62 Mb | Chr 6: 125.03 - 125.05 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Vidi još uredi
Reference uredi
- ↑ Adhr, Consortium; Strom, Tim M.; White, Kenneth E.; Evans, Wayne E.; O'Riordan, Jeffery L.H.; Speer, Marcy C.; Lorenz-Depiereux, Bettina; Grabowski, Monika i dr.. (Dec 2000). „Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23”. Nat Genet 26 (3): 345–8. DOI:10.1038/81664. PMID 11062477.
- ↑ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). „Discovery and mapping of ten novel G protein-coupled receptor genes”. Gene 275 (1): 83–91. DOI:10.1016/S0378-1119(01)00651-5. PMID 11574155.
- ↑ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (Aug 2006). „GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5”. J Biol Chem 281 (33): 23589–97. DOI:10.1074/jbc.M603670200. PMID 16774927.
- ↑ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B (Jul 2006). „Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes”. J Pharmacol Exp Ther 318 (2): 619–28. DOI:10.1124/jpet.105.098848. PMID 16651401.
- ↑ „Entrez Gene: GPR92 G protein-coupled receptor 92”.
- ↑ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). „LPA Receptors: Subtypes and Biological Actions”. Annual Review of Pharmacology and Toxicology 50 (1): 157–186. DOI:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.[mrtav link]
Literatura uredi
- Takeda S, Kadowaki S, Haga T, et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”. FEBS Lett. 520 (1-3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.